Effort and yield of implementing EEG source localisation in presurgical epilepsy evaluation

Effort and yield of implementing EEG source localisation in presurgical epilepsy evaluation - Start-ESL

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00023852

Enrollment

Registered

2021-03-03

Start date

2021-07-12

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pharmacoresistant focal epilepsy G40

Interventions

Group 1: 1) Assessment of the time spent for inhouse ESL during multimodal non-invasive presurgical epilepsy evaluation. 2) Comparison of ESL results to other diagnostic findings and, if applicable, t

Eligibility

Sex/Gender

All

Age

14 Years to No maximum

Inclusion criteria

Inclusion criteria: Pharmacoresistant focal epilepsy; non-invasive evaluation for a first resective epilepsy surgery at the EZBB

Exclusion criteria

Exclusion criteria: Lack of written informed consent; skull defect

Design outcomes

Primary

Measure	Time frame
As a measure of the effort for ESL, the first primary endpoint is the working time for processing each single case as well as for installation and maintenance of the IT infrastructure per month. As a measure of the benefit of newly implemented ESL, the second primary endpoint is the concordance of selfmade ESL results (a) with externally processed, CE-certified ESL as external reference standard, and (b) with the resected brain area with respect to 12-month postsurgical seizure outcome.	—

Measure

Time frame

As a measure of the effort for ESL, the first primary endpoint is the working time for processing each single case as well as for installation and maintenance of the IT infrastructure per month. As a measure of the benefit of newly implemented ESL, the second primary endpoint is the concordance of selfmade ESL results (a) with externally processed, CE-certified ESL as external reference standard, and (b) with the resected brain area with respect to 12-month postsurgical seizure outcome.

—

Secondary

Measure	Time frame
Secondary endpoints include the concordance of ESL findings with results of other localising diagnostic methods (seizure semiology, MRI, etc.), a comparison of two non-commercial ESL software packages, the medical team's subjective estimation whether ESL brought a gain of knowledge for the individual case, and 12-month postsurgical outcome of the patients evaluated with ESL in comparison to matched control patients operated without ESL.	—

Measure

Time frame

Secondary endpoints include the concordance of ESL findings with results of other localising diagnostic methods (seizure semiology, MRI, etc.), a comparison of two non-commercial ESL software packages, the medical team's subjective estimation whether ESL brought a gain of knowledge for the individual case, and 12-month postsurgical outcome of the patients evaluated with ESL in comparison to matched control patients operated without ESL.

—

Countries

Germany

Contacts

Public ContactBernd Vorderwülbecke

Charité - Universitätsmedizin Berlin, Klinik für Neurologie

bernd.vorderwuelbecke@charite.de+49 (0)30 450 560 038

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Apr 4, 2026