The influence of thyroid hormone substitution on physical performance in patients with diagnosed hypothyroidism

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00023787

Enrollment

Registered

2020-12-04

Start date

2020-12-20

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E03.9

Interventions

Group 1: Observational study: Patients with diagnosed hypothyroidism undergo various athletic performance tests during the dose-finding phase (to identify the individually appropriate medication and d

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: - Female - Diagnosed hypothyroidism - Diagnosis is four weeks or less ago - Thyroid hormone substitution - Premenopausal (18-35 years) - Regular cycle

Exclusion criteria

Exclusion criteria: - Above average sports workload (more than one hour three days a week or three hours a week) - Diagnosis was made more than four weeks ago - Hormone substitution (including oral contraceptives; excluding thyroid hormones) - Hormonal diseases (Exception: hypothyroidism) - Cardiac arrhythmias in need of treatment Metabolic diseases - Heart failure (EF <50) - Performance limiting pAVK (Fontaine Stadium = II) - Performance-limiting respiratory diseases - Performance limiting degenerative diseases - Performance limiting muscular diseases - Performance-limiting kidney diseases - Performance limiting neurological diseases - Psychiatric and / or addiction disorders - Performance-limiting oncological diseases in the history (< 5 years)

Design outcomes

Primary

Measure	Time frame
A total of at least 25 patients are planned to be included in the study. The study will be completed when all participants have completed all examinations on the third day of measurement. The following examinations are performed: - Venous blood collection (TSH, fT4, fT3) - Questionnaire SF-36 - Body height - Body weight - Bio-Impedance Analysis - Calorimetry - Sit and Reach Test - Shoulder lift test - Vertical Jump Test - Dynamometer - Chest press (3 RM) - Leg extension (3 RM) - Curl-Ups - push-ups max. repetitions in 60 seconds - level test WHO scheme on the bicycle ergometer	—

Measure

Time frame

A total of at least 25 patients are planned to be included in the study. The study will be completed when all participants have completed all examinations on the third day of measurement. The following examinations are performed: - Venous blood collection (TSH, fT4, fT3) - Questionnaire SF-36 - Body height - Body weight - Bio-Impedance Analysis - Calorimetry - Sit and Reach Test - Shoulder lift test - Vertical Jump Test - Dynamometer - Chest press (3 RM) - Leg extension (3 RM) - Curl-Ups - push-ups max. repetitions in 60 seconds - level test WHO scheme on the bicycle ergometer

—

Secondary

Measure	Time frame
see primary endpoint	—

Countries

Germany

Contacts

Public ContactLars Hanke

Institute of Cardiology and Sports Medicine, German Sport University Cologne

Lars.hanke@stud.dshs-koeln.de+49 15735531965

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026