G43.0 G43.1
Conditions
Interventions
Group 1: cMRI in all migraine patients with and without aura
Group 2: Performing a cMRI 6 months after changing the prophylactic therapy- Patients who got an cMRI in Arm 1, will get a second cMRI afte
Sponsors
Klinik für Neurologie und Neurophysiologie Uniklinik Freiburg
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patient suffering from migraine with/without aura and with/without prophylaxis All migraine patients are included if they fulfill the following criteria: a.) episodic or chronic migraine with or without aura (had at least one attack in life) b.) female and male sex c.) < 65 years old
Exclusion criteria
Exclusion criteria: Excluded are all patients for whom the above does not apply, taking opiates (opiates act on the pain system and can falsify the cMRI data), patients suffering from further headaches or facial pain (except tension headache), pregnancy or lactation, contraindications against cMRI (pacemaker), other metal implants which are contraindicated and the lack of the possibility to oral and written information. Patients over 65 years are not included because they may develop more cardiovascular diseases and cerebral microvascular changes etc., which could falsify the MRI results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arm 1.) Significant changes in white and grey matter (pain matrix) in migraine patients (with and without aura) compared to healthy controls (diffusivity/voxel-based morphometry) Arm 2.) Significant changes in the pain matrix (diffusivity/voxel-based morphometry) due to migraine prophylaxis | — |
Secondary
| Measure | Time frame |
|---|---|
| Arm 1.) none Arm 2.) The changes in the accompanying symptoms (e.g. nausea/vomiting, photo-phonophobia, etc.) correlate with diffusivity/voxel-based morphometry | — |
Countries
Germany
Contacts
Public ContactCharlotte von Kageneck
Klinik für Neurologie und Neurophysiologie Uniklinik Freiburg
Outcome results
None listed