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Evaluation the effect of Injectable Plasma Rich Fibrin (I-PRF) in reducing the resorption of fat graft during facial lipostructure : A randomized clinical trial

Evaluation the effect of Injectable Plasma Rich Fibrin (I-PRF) in reducing the resorption of fat graft during facial lipostructure : A randomized clinical trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
DRKS
Registry ID
DRKS00023758
Enrollment
20
Registered
2020-12-11
Start date
2021-01-31
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy patients with nasofacial fold

Interventions

Group 1: Fat preparation: The adipose tissue was extracted from umbilical. The extraction was carried out by means of a special aspiration nozzle with a diameter of 3 mm and a length of 15 cm, with fo
there were variations between patients depending on the indication and the amount required for re-injection. The next step in the clean-up process was to centrifuge the extracted tissue. The 10-mL syr

Sponsors

Department Oral medicine, Faculty of Dental Medicine, Damascus University, AlMazaa
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1- Patients aged 18 years old and more 2- Patients who have a visible wrinkle that score 2 or 3 based on MFWS scale (Moderate wrinkle to deep wrinkle)

Exclusion criteria

Exclusion criteria: Exclusion criteria 1- patients aged under 18 years old 2- presence of any systemic disease that affects the inflammatory response 3. Patients who have had previous facial reconstruction surgery by lipid or any other filler 4. Patients with a history of severe weight gain or loss in the previous months. 5. Patients with bleeding disorders.

Design outcomes

Primary

MeasureTime frame
The follow-up recalls were conducted after 1, 3, 6, and 12 months for all participants. five investigators evaluated pre- and postsurgical intervention using photographic pictures based on Modified Fitzpatrick Wrinkle Scale (MFWS). All reviewers were masked as to which side received the treatment A or B, as well as they were blinded as to the different reviewer responses

Countries

Syria

Contacts

Public Contactlaith Alsabek

Damascus University

alsabeklaith@gmail.com+963937178467

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026