bacterial dental plaque K05.6
Conditions
Interventions
Group 1: Antibacterial effects
Group 2: Substantivity
Group 3: Acceptance by study-participants
Sponsors
Klinik für Parodontologie und peri-implantäre Erkrankungen
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: At the age between the age of 18-70 years; In good health; With least 20 own teeth (excluding wisdom teeth); Reassurement of an effective contraception; Non-smokers or former smokers for at least 1 year or occasional smokers with a maximum of 5 cigarettes per week; Willing not to use interdental cleaning devices that contain antibacterial agents, like amine fluoride, chlorhexidine, silver ions etc. during the full duration of the study.
Exclusion criteria
Exclusion criteria: 1. Severe systemic diseases (e.g. tumours, infectious diseases) and diseases that require regular systemic drugs (e.g., Anti-Hypertensives: Ca-Antagonists); 2. The use of systemic antibiotics during the last 3 months or local antimicrobials that may affect the plaque biofilm (antibacterial mouth rinses (e. g. chlorhexidine) 4 weeks or less prior recruitment); 3. Severe oropharyngeal infections, significant dental disorders, ongoing dental treatment or any other medical treatment of the oral cavity; 4. Any known allergy to previously used oral hygiene products and/or oral therapeutic agents and/or dental materials or a known allergy to any of the ingredients of the study products or standard toothpaste (e.g. Limonene), which are used during the study and the wash-out periods; 5. Participants with current periodontitis or non-physiological tooth mobility, any other pathological change of the oral mucosa or gingiva, poor oral hygiene (papilla bleeding index PBI >30%); 6. Chronic drug abuse (alcohol, etc.) or any other illness which does not allow the person to assess the nature and/or possible consequences of the study; 7. Smoking with more than 5 cigarettes per week,; 8. Participation in another clinical study within the previous 30 days or parallel to this study; 9. dual participation in this or another clinical study during the clinical phase; 10. Individuals unwilling to abstain from additional oral hygiene measures during the treatment phase; 11. Non-Caucasians and women being pregnant or breast feeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vitality of dental plaque flora using vital fluorescence. Biofilm vitality (VF) after 24 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| Acceptance using Visual Analogue Scale (VAS) questionnaires. | — |
Countries
Germany
Contacts
Public ContactNicole Arweiler
Klinik für Parodontologie und peri-implantäre Erkrankungen
Outcome results
None listed