Influence of the anesthetic procedure on the exosomal micro-RNA signature in patients undergoing radical cystectomy

Influence of the anesthetic procedure on the exosomal micro-RNA signature in patients undergoing radical cystectomy - ExoRZE

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00023682

Enrollment

300

Registered

2020-11-25

Start date

2020-11-29

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C67

Interventions

Group 1: anesthetic regimen: sevoflurane Group 2: anesthetic regimen: total intravenous anesthesia (TIVA)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: • Written declaration of consent • planned radical cystectomy with urinary diversion • Age = 18 years • Epidural anesthesia in combination with standard anesthesia (balanced or TIVA) • "enhanced recovery after surgery" protocol • ASA II-III

Exclusion criteria

Exclusion criteria: • Refusal of participation by the patient • Language barrier • Age <18 years • clinically relevant aortic stenosis

Design outcomes

Primary

Measure	Time frame
Influence of the anesthetic regimen (epidural anesthesia + balanced anesthesia (sevoflurane) and epidural anesthesia + TIVA propofol / fentanyl) on exosome and miRNA concentration in cystectomy patients Withdrawal of 10 ml of blood from a lying arterial catheter at the following times: 1. After arterial catheter placement 2. before skin incision 3. 30 minutes after cutting 4. before skin suture 5. after 24 hours. Serum extraction and determination of the exosome concentration in the serum. miRNA extraction from the serum and determination of the miRNA signature in exosomes	—

Measure

Time frame

Influence of the anesthetic regimen (epidural anesthesia + balanced anesthesia (sevoflurane) and epidural anesthesia + TIVA propofol / fentanyl) on exosome and miRNA concentration in cystectomy patients Withdrawal of 10 ml of blood from a lying arterial catheter at the following times: 1. After arterial catheter placement 2. before skin incision 3. 30 minutes after cutting 4. before skin suture 5. after 24 hours. Serum extraction and determination of the exosome concentration in the serum. miRNA extraction from the serum and determination of the miRNA signature in exosomes

—

Secondary

Measure	Time frame
Deviations in the micro-RNA signature in the course of anesthesia over time in radical cystectomy comparison of hypotension phases and hemodynamics between groups	—

Countries

Germany

Contacts

Public ContactUlrich Frey

Ruhr-Universität Bochum Marienhospital Herne Klinik für Anästhesiologie, operative Intensivmedizin, Schmerz- und Palliativmedizin

ulrich.frey@ruhr-uni-bochum.de+49 2323 499 1401

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026