G44.3
Conditions
Interventions
Group 1: Patients with posttraumatic headache are examined at baseline and 3 months later.
Group 2: The healthy control group is examined at baseline.
Sponsors
Neurologische KlinikBG Universitätsklinikum Bergmannsheil gGmbH
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients: - Acute or persistent headache resulting from a traumatic head injury - The headache developed within 7 days of any of the following: the head injury, regaining consciousness after the head injury, discontinuation of medication that interferes with the ability to feel or report a headache after the head injury - The headache is not better explained by another ICHD-3 diagnosis Inclusion criteria for healthy control subjects: - none of the exclusion criteria is met - Present declaration of consent - No abnormal result in the questionnaire or physical examination - no use of drugs with peripheral or central nervous effects /side effect - no neurological or psychiatric illness
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients: - Age 7 days in the last 4 months - Treatment with topical capsaicin in the past 6 months - Epilepsy treated with anticonvulsants - Psychiatric illness treated with anticonvulsants or antidepressants with a proven effect on neuropathic pain - Other pain localization with a pain intensity =6 (NRS 0-10) on =15 days / month - Other severe systemic or focal CNS affection - Other central or peripheral neurological disorders - peripheral arterial occlusive disease (except for stage Fontaine I) - Serious cognitive or psychiatric impairment Exclusion criteria for healthy control subjects: - Age 2 (NRS 0-10) - Current pain intensity >0 (NRS 0-10) - Insufficient knowledge of German or other communication problems - Neuropathies, radiculopathies, or nerve lesions - Chronic pain syndromes - Treatment with topical local anesthetics for the past 6 weeks - Treatment with topical capsaicin in the past 6 months - Epilepsy treated with anticonvulsants - Psychiatric illness treated with anticonvulsants or antidepressants with a proven effect on neuropathic pain - Other severe systemic or focal CNS affection - Other central or peripheral neurological disorders - peripheral arterial occlusive disease (except for stage Fontaine I) - Serious cognitive or psychiatric impairment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Amplitude height of the PREP of patients with posttraumatic headache compared with healthy control group 2) Height of the CPM effect based on the pain intensity compared to the control group 3)Height of the CPM effect based on the stimulus amplitude compared to the control group | — |
Secondary
| Measure | Time frame |
|---|---|
| 4) correlation between headache intensity and PREP amplitude 5) correlation between headache intensity and CPM effect 6) correlation between headache duration and CPM effect difference compared to control group | — |
Countries
Germany
Contacts
Public ContactElena Enax-Krumova
Neurologische KlinikBG Universitätsklinikum Bergmannsheil gGmbH
Outcome results
None listed