Healthy Volunteers
Conditions
Interventions
Group 1: Constant "background" light profile of photoreceptor activation matched to daylight at 6500K (used during first experimental visit)
Group 2: Sinusoidally flickering (1Hz) light with low stimu
+37% L+M cone contrast from background).
Group 3: Sinusoidally flickering (1Hz) light with higher stimulation of S-cones, but decreased brightness (blue-dim: +37% S-cone contrast, –37% L+M contrast fr
Sponsors
FWF Wissenschaftsfonds
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: • Age: 18-35 years • Body Mass Index: 18.5-24.9 (i.e. normal weight according to WHO criteria) • Informed consent as documented by signature of the participant
Exclusion criteria
Exclusion criteria: • Previous enrollment in the study’s project part • Investigator’s family members, employees or other dependent persons • Self-reported photosensitive epilepsy • Pregnancy • Chronic or debilitating medical conditions • Drug use • Abnormal colour vision as established in the Cambridge Colour Test • Shift work 2 time zones) < 1 month prior to beginning of the study • Extreme chronotype • Short and long sleep duration (subjective sleep duration on workdays outside 6-10h according to the MCTQ) • Inability to understand and/or follow procedures • Non-adherence to sleep/wake times during the ambulatory part (i.e. protocol for the stabilization of the sleep-wake cycle
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Phase shift, i.e. difference in DLMO between the first evening of each experimental visit and the second evening. | — |
Secondary
| Measure | Time frame |
|---|---|
| • The time course (t1, t2, …tn) of visual comfort ratings • The time course (t1, t2, …tn) of median reaction time, 10% fastest reaction times, 10% slowest reaction times • EEG-derived sleep onset latency • EEG-redived slow wave activity (SWA) during the first sleep cycle | — |
Countries
Switzerland
Contacts
Public ContactChristine Blume
Universität Basel
Outcome results
None listed