healthy volunteers
Conditions
Interventions
Group 1: Bone marrow aspiration. Subsequently, transcriptome sequencing of B precursor cells.
Sponsors
Universitätsklinikum Schleswig-Holstein Campus Kiel
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Full legal age, absence of hematological diseases, no medication with possible interactions with haematopoeisis, no chronically inflammatory diseases
Exclusion criteria
Exclusion criteria: Underlying hematological diseases, medication with possible interactions with haematopoesis, chronically inflammatory diseases, probably difficult conditions for bone marrow puncture
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This project aims to define the developmental origin of the different molecular subtypes of ALL and to identify leukemia-specific gene expression in contrast to gene regulation during normal lymphopoiesis. Characterization of the disease-specific gene regulation will guide us to explore oncogenic signaling dependencies as novel therapeutic targets. | — |
Countries
Germany
Contacts
Public ContactBjörn-Thore Hansen
Universitätsklinikum Schleswig-Holstein Campus Kiel
Outcome results
None listed