Scivias study - New biomarkers for diseases in childhood

Scivias study - New biomarkers for diseases in childhood - Scivias

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00023566

Enrollment

5000

Registered

2020-12-18

Start date

2021-01-18

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diseases in childhood with an emphasis on disorders of the immune system and metabolism

Interventions

Group 1: In the study images of the retina are taken using non-invasive methods of fundus photography, optical coherence tomography (OCT) and OCT angiography (thanks to technical advances mydriasis is

Eligibility

Sex/Gender

All

Age

3 Years to 18 Years

Inclusion criteria

Inclusion criteria: 1. Age between 3 and 18 years 2. Existing consent ("informed consent" and "informed assent")

Exclusion criteria

Exclusion criteria: no cooperation by the child (no "informed assent")

Design outcomes

Primary

Measure	Time frame
Primary study objective: Identification of new biomarkers for the overall assessment of the systemic health status of children	—

Secondary

Measure	Time frame
Secondary study objectives: 1. Establishment of a normal range for fundus photography, OCT and OCT angiography with regard to retinal changes in various age groups 2. Evaluation of the value of optical fundus evaluation in (early) diagnosis of a rare disease 3. Establishing a reference range for changes in the transcriptome, metabolome and proteome in various age groups and in various acute and chronic diseases 4. Correlation of systems biology data with disease activities of rare diseases 5. Specification of phenotyping of patients within different disease groups	—

Measure

Time frame

Secondary study objectives: 1. Establishment of a normal range for fundus photography, OCT and OCT angiography with regard to retinal changes in various age groups 2. Evaluation of the value of optical fundus evaluation in (early) diagnosis of a rare disease 3. Establishing a reference range for changes in the transcriptome, metabolome and proteome in various age groups and in various acute and chronic diseases 4. Correlation of systems biology data with disease activities of rare diseases 5. Specification of phenotyping of patients within different disease groups

—

Countries

Germany

Contacts

Public ContactKatharina Danhauser

Dr. von Haunersches Kinderspital - Klinikum der LMU München

scivias.hauner@med.uni-muenchen.de+49 89 4400 52811

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026