E84
Conditions
Interventions
Group 1: 2 timepoints: before therapy start with CFTR modulator and after 6 months
examinations: spirometry, sweat test, functional immunomonitoring
Sponsors
Institute of Clinical and Experimental Trauma Immunology, University Hospital Ulm
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age at least 18 years; indication for Kaftrio therapy; homozygous deltaF508 mutation or compound heterozygous for deltaF508 and a minimal function mutation
Exclusion criteria
Exclusion criteria: acute infection, fever or surgical intervention within the last 7 days; blood transfusion within the last 3 months; immunosuppressive therapy; systemic antibiotic therapy within the last 3 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| experimental parameters of neutrophil function timepoints: before start of CFTR modulator therapy and 6 months afterwards methods: flow cytometry | — |
Secondary
| Measure | Time frame |
|---|---|
| lung function parameters timepoints: before start of CFTR modulator therapy and 6 months afterwards methods: spirometry | — |
Countries
Germany
Contacts
Public ContactHanna Schmidt
Department of Pediatric and Adolescent Medicine, University Hospital Ulm
Outcome results
None listed