F00.0 F00.1
Conditions
Interventions
Group 1: It is planned to enroll 30 volunteer test persons in the stage of mild dementia of the Alzheimer's type or patients with the syndrome of mild cognitive impairment (“mild cognitive impairment”
Sponsors
Deutsche Alzheimer Gesellschaft e. V. Selbsthilfe Demenz, vertreten durch die Geschäftsführerin
Eligibility
Sex/Gender
All
Age
66 Years to No maximum
Inclusion criteria
Inclusion criteria: - Women and men (> 65 years) with mild AD (MMST = 20) - Women and men (> 65 years) with MCI and a pathological CSF profile (Aß1-42 decreased, tau protein increased) - Women and men (> 65 years) as healthy control subjects (MMST> 27) - Obtained consent and information ability - Willingness to take swabs of the oral mucosa and gums
Exclusion criteria
Exclusion criteria: - Acute infections of the upper respiratory tract - Known acute inflammations in the oral cavity (e.g. stomatitis) - Serious physical illnesses with impairment of the general condition, fever or current weight loss of more than 2 kg in the past four weeks, palliative life situation - Malnutrition (body mass index below 18.5 kg / m2) - Other neurological diseases (stroke, multiple sclerosis, epilepsy, Parkinson's disease) or severe psychiatric comorbidities such as an addiction disorder or schizophrenic psychosis - Potentially reversible causes of cognitive deficits (e.g. vitamin B12 deficiency)
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Provide pathophysiological information on the genesis of the disease. Clinically, this could result in a diagnostic approach to early diagnosis, but it could also lay the foundation for therapeutic alternatives. | — |
Primary
| Measure | Time frame |
|---|---|
| Relationship between the oral microbiome and the development of AD, identification of relevant germs for the development of AD | — |
Countries
Germany
Contacts
Public ContactJulia Christl
LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine Universität
Outcome results
None listed