PRETWINSCREEN - A multi-disciplinary approach for a personalized prenatal diagnostics and care for twin pregnancies

PRETWINSCREEN - A multi-disciplinary approach for a personalized prenatal diagnostics and care for twin pregnancies - PRETWINSCREEN

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00023441

Enrollment

1200

Registered

2020-11-02

Start date

2021-04-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

O30.0 O43.0 O36.5 O14.9

Interventions

Group 1: Twin pregnancy Patients with existing twin pregnancies (both monochorial and dichorial) will be included in the study after written consent has been obtained. After recruitment, intensive ca

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Mother's ability to consent - Signed declaration of consent - Presence of a twin pregnancy - gestational age <13+6 weeks at time of inclusion

Exclusion criteria

Exclusion criteria: - death of a twin 2 fetuses) - Indication for termination of pregnancy from maternal indication

Design outcomes

Primary

Measure	Time frame
We aim to develop a multi-marker, personalized, and predictive model for prenatal identification of twin pregnancies that are at risk for developing feto-maternal complications so that better care and preventive measures can be offered.	—

Secondary

Measure	Time frame
The following complications should be checked and evaluated by the register: - Proportion of study participants with one of the following complications: o Preeclampsia (PE) o Gestational diabetes (GDM, dietary adjusted or insulin required) o Feto-fetal transfusion syndrome (TTTS, twin-to-twin transfusion syndrome) o Selective intrauterine growth restriction (sIUGR, selective intrauterine growth restriction) - Causes of death intrauterine - Proportion of study participants with necessary intervention during pregnancy due to one of the above mentioned complications: o Intrauterine laser therapy with TTTS o Cord-clamping at sIUGR o Amniotic drainage o Invasive prenatal diagnostics (AC, CVS) for fetal chromosomal abnormalities o Antihypertensive or anticonvulsive therapy for PE o Insulin therapy for insulin-dependent GDM - Birth / Premature birth o Average age at birth o Birth weight (Z-scores; percentiles) or weight difference between fat 1 and 2 o Maternal morbidity / mortality o Childhood morbidity / mortality - Number of AEs / adverse outcomes (prenatal, postnatal) - maternal and infantile - Average number of days of maternal and neonatal hospitalization due to complications	—

Measure

Time frame

The following complications should be checked and evaluated by the register: - Proportion of study participants with one of the following complications: o Preeclampsia (PE) o Gestational diabetes (GDM, dietary adjusted or insulin required) o Feto-fetal transfusion syndrome (TTTS, twin-to-twin transfusion syndrome) o Selective intrauterine growth restriction (sIUGR, selective intrauterine growth restriction) - Causes of death intrauterine - Proportion of study participants with necessary intervention during pregnancy due to one of the above mentioned complications: o Intrauterine laser therapy with TTTS o Cord-clamping at sIUGR o Amniotic drainage o Invasive prenatal diagnostics (AC, CVS) for fetal chromosomal abnormalities o Antihypertensive or anticonvulsive therapy for PE o Insulin therapy for insulin-dependent GDM - Birth / Premature birth o Average age at birth o Birth weight (Z-scores; percentiles) or weight difference between fat 1 and 2 o Maternal morbidity / mortality o Childhood morbidity / mortality - Number of AEs / adverse outcomes (prenatal, postnatal) - maternal and infantile - Average number of days of maternal and neonatal hospitalization due to complications

—

Countries

Canada, Germany, Israel, Spain, United Kingdom

Contacts

Public ContactAnnegret Geipel

Abteilung für Geburtshilfe und Pränatale MedizinUniversitätsklinikum Bonn

annegret.geipel@ukbonn.de+49-228-287 37116

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026