K05.3
Conditions
Interventions
Group 1: coenzyme Q10 containing spray (ParoMit® Q10 spray), 7 days: 2x per day 10 sprays, 21 days: 2x per day 5 sprays
Group 2: placebo spray, 7 days: 2x per day 10 sprays, 21 days: 2x per day 5 spra
Sponsors
Dr. med. Schütze GmbH
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: • gender male or female, age between 40 and 70 years • ability to give informed consent • voluntary participation • caries-free, sufficently treated teeth (D-T = 0) • generalized periodontitis stage III-IV • periodontal treatment need according to periodontal chart • at least 20 remaining teeth • BOP = 30%, PD = 5mm at = 35% of the probing sites • pretreatment: 2 professional teeth cleaning with an interval of 2-3 weeks before the periodontal chart
Exclusion criteria
Exclusion criteria: • planned adjuvant antibiotic treatment in the periodontal treatment • less than 20 remaining teeth • BOP < 30 % • last systematic scaling and root planing in the last 24 months • smoker • antibacterial, anti-inflammatory or immunosuppressive medication in the last 3 months before and during the study • local antiseptic or antibacterial treatment in the last 4 weeks before and during the study • known intolerance against ingredients of the used spray, toothpaste or other in the study used materials • patients with significantly reduced / missing fine motor skills • not feasible investigation due to poor general condition • patients with significantly reduced salivation/ xerostomia • patients with dementia • immunosuppressed patients: transplanted organs, autoimmune disease (e.g. chronical intestine diseases, rheumatoid arthritis • hepatitis A/B/C, tuberculosis, HIV (upon request) • diabetes mellitus • participants that would need an antibiotic prophylaxis (e.g. risc for endocarditis, immunosuppression) • participants with epileptic or neurological disorders • addicts • pregnant or nursing women (upon request)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bleeding on Probing (BOP) and pocket depths (PD) after 6 weeks, 3, 6 and 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| attachementlevel (AL), papillary bleeding index (PBI), gingiva index (GI), side effects, rating by the patient | — |
Countries
Germany
Contacts
Public ContactDirk Ziebolz
Poliklinik für Zahnerhaltung und Parodontologie, Universitätsklinikum Leipzig
Outcome results
None listed