Combined structural and functional analysis of micro- and macrovascular changes in pediatric patients with hypercholesterolemia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00023414

Enrollment

Registered

2020-12-03

Start date

2017-11-21

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E78.0

Interventions

Group 1: hypercholesterolemia the following analyses are performed: 1) Visualization of the sublingual vessels with Sidestream Darkfield Imaging and analysis of the microcirculation and the endothel

GlyockCheck) 2) Ananlysis if the endothelia function by measurements of the Reactive Hyperemia Index (RHI) and the Augmentation Index (AI) using peripheral aterial tonometry 3) measurement of the inti

Eligibility

Sex/Gender

All

Age

10 Years to 17 Years

Inclusion criteria

Inclusion criteria: suspected familial hypercholesterolemia, LDL-cholesterol > 130mg/dL

Exclusion criteria

Exclusion criteria: • acute infectious disease • other illnesses that are accompanied by chronic inflammation and/or increased cardiovascular risk (e.g. Diabetes mellitus, chronic inflammatory bowel disease) • secondary hypercholesterolemia (e.g. due to chronic kidney disease)

Design outcomes

Primary

Measure	Time frame
thickness of sublingual glycocalyx, serum glycocalyx degradation products (hyaluronan, syndecan-1), endothelial function as determinde by reactive hyperemia index	—

Secondary

Measure	Time frame
cIMT, pro-inflammatory cytokines (TNF-alpha), ox LDL, arterial stiffness (augmentation index)	—

Countries

Germany

Contacts

Public ContactClaudia Nussbaum

Campus Innenstadt Dr. von Haunersches Kinderspital LMU München

claudia.nussbaum@med.uni-muenchen.de+49 89/4400-54535

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026