Healthy volunteers
Conditions
Interventions
Group 1: Exposure 1 - [normobaric hypoxia]: 6.5 hours of exposure to air with an oxygen
fraction of 15%, i.e. reduced O2 partial pressure to 152 mbar, at normal ambient
pressure.
Group 2: Exposure 2
Sponsors
Deutsches Zentrum für Luft- und Raumfahrt (DLR)Institut für Luft- und Raumfahrtmedizin Schlaf und Humanfaktoren
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: - Healthy - Written consent after clarification - 1-week caffeine and alcohol abstinence before the start of the study - fluent in the German language
Exclusion criteria
Exclusion criteria: - Acute or chronic diseases that are not compatible with the study - Usual bedtime before 21:30 or after 00:30 on working days - Usual time to get up before 05:30 or after 8:30 on working days - Former heparin-induced thrombocytopenia (HIT) - Bleeding or high risk of bleeding - Known or suspected blood clotting disorder - Known or suspected allergy to heparin - Insomnia - Regular shift and/or night work within the last 3 months - Travelling across multiple time zones in the last months - BMI =30 or <18 - All drugs that influence the parameters of the examination - Alcohol and/or drug addiction - Above average caffeine consumption - Pregnancy (early pregnancy test before each study period) - Drug use or smoking (multi-drug test before each study period) - Extremely intensive training during the outpatient monitoring days (7 days before each study phase) - Disease with prolonged bed rest within 6 weeks before study start - Fear of taking blood samples - Barely assessable superficial veins (will be assessed at the preliminary examination) - Blood donation within 3 months before study start - Claustrophobia (fear of staying in closed rooms)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in clock time of venous plasma DLMO before and after exposure to an interval of hypoxia, and before and after an interval of normoxia (control). The time shift in DLMO between constant posture (CP) 2 and 1 will be compared to the difference between 4 and 3 | — |
Countries
Germany
Contacts
Public ContactTitiaan Post
Deutsches Zentrum für Luft- und Raumfahrt (DLR)Institut für Luft- und Raumfahrtmedizin Schlaf und Humanfaktoren
Outcome results
None listed