chemotherapy-induced-dysgeusia caused by one of the following cancer types: breast, ovarian, endometrial, pancreas, colorectal, lung, prostate cancer, urothelial carcinoma, germ cell tumor or sarcoma and lymphomas
Conditions
Interventions
Group 1: acupuncture (1x/week over 8 weeks) and acupressure (daily self-acupressure over 8 weeks) for cancer-related fatigue with additional dysgeusia specific acupuncture and acupressure points
Group
Sponsors
Institut für komplementäre und integrative Medizin UniversitätsSpital Zürich
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - indication of supportive routine care acupuncture treatment for fatigue, with a fatigue intensity of at least 3 on a numeric rating scale (NRS 1-10) - dysgeusia of at least 5 on NRS (=moderate dysgeusia, NRS 1-10) in the screening tool (adapted from Zabernigg A. et al., 2010) - actually treated with a chemotherapy regime that includes taxanes, platinum-based antineoplastic drugs or antrazyclins - chemotherapy treatment is planned to continue at least 8 weeks after beginning of acupuncture treatment - breast, ovarian, endometrial, pancreas, colorectal, lung, prostate cancer, urothelial carcinoma, germ cell tumor or sarcoma - lymphomas with bone marrow infiltration <50% that are under treatment with antrazyclins - performance status of ECOG 0-1 - can eat normal food without pain or swallowing problems - internet access and interested to use e-learning
Exclusion criteria
Exclusion criteria: - currently receive acupuncture treatment - dysgeusia that occurred independently of the chemotherapy treatments of the current cancer - confirmed positive COVID-19 test with associated dysgeusia prior to chemotherapy treatment - increased risk of bleeding e.g. caused by haemophilia or platelets<50000 µl - coexisting MDS - don’t speak sufficient German - mucositis and dysgeusia with an impact on nutrition (pain or swallowing problems) - currently receiving or have a planned radiotherapy during the intervention period (within the next 12 weeks) in the head/neck area
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perceived dysgeusia over 8 weeks, calculated as the mean from two patient reported items on taste, each measured on a numeric rating scale from 1-10 weekly directly after each acupuncture treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Taste and smell test, at 4 and 8 weeks; weight loss, at 4 and 8 weeks; perceived dysgeusia, fatigue, distress, nausea and vomiting, odynophagia, xerostomia and polyneuropathy (diary), with daily measures over 8 weeks and after 12 and 24 weeks; quality of life, at 4, 8, 12 and 24 weeks. | — |
Countries
Switzerland
Outcome results
None listed