S06 I63
Conditions
Interventions
Group 1: The study aims to examine and determine the microbiological condition, viability and the
Infection potential of different cryopreserved Bone flaps (subgroup A: -20
Degree
Subgroup B: -80 degrees
Subgroup C: Computer-made Bone flaps, CAD).
Sponsors
Director, Department of Neurosurgery ,Katholisches Klinikum Lünen/Werne (KKLW)
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: The patients, who have been in the Neurosurgical Clinic at the Catholic Klinikum Lünen / Werne Bone flaps explanted, which in the context of an Exitus letalis were not re-implanted.
Exclusion criteria
Exclusion criteria: none
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The comparison of the microbiological status between explanted Bone flaps (subgroup A vs. subgroup B) using microbiological culture. The comparison of the bony microarchitecture of the explanted Bone flaps (subgroup A vs. subgroup B) using microscopy and the expression analysis of biomarkers of bone viability (parathyroid hormone type I receptor (PTH1R), osteoprotegerin (OPG), receptor of NFkB (RANKL), osteocalcin, C-terminal telopeptide) using immunohistochemistry (Subgroup A vs. subgroup B) in the explanted cranial bone (cortex and spongiosa) | — |
Secondary
| Measure | Time frame |
|---|---|
| The comparison of the infection potential after contamination of the explanted Bone flaps and the CAD with specific bacterial strains, i.e. whether pathogens grow at different speeds in the various subgroups. (Subgroup A vs. Subgroup B vs. Subgroup C) | — |
Countries
Germany
Contacts
Public ContactRachit Agrawal
Neurosurgical Resident, Katholisches Klinikum Lünen/Werne ( KKLW)
Outcome results
None listed