Transcranial versus Direct Cortical Stimulation for Motor Evoked Potentials during Resection of Supratentorial Tumors under General Anesthesia (the TRANSEKT-Trial), a Randomized Controlled Study

Transcranial versus Direct Cortical Stimulation for Motor Evoked Potentials during Resection of Supratentorial Tumors under General Anesthesia (the TRANSEKT-Trial), a Randomized Controlled Study - TRANSEKT

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00023256

Enrollment

120

Registered

2020-10-29

Start date

2020-12-03

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C71.0 C71.1 C71.2 C71.3

Interventions

Group 1: Resection of a supratentorial tumor under transcranial electrical stimulation for monitoring of motor evoked potentials Group 2: Resection of a supratentorial tumor under direct cortical stim

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1- Indication for surgical resection of a supratentorial tumor. 2- Suspected supratentorial glioma or metastasis in close vicinity to the corticospinal tract without Infiltration of the precentral gyrus, confirmed in a preoperative magnetic resonance imaging. 3- Missing or mild preoperative paresis (MRC grades 5 or 4) 4- Age => 18 and =< 80 years 5- Ability to give informed consent.

Exclusion criteria

Exclusion criteria: 1- Age 80 years 2- Preoperative MRI is not available 3- Severe preoperative paralysis (MRC grades 1,2 or 3) 4- One of the stimulation modalities is not appropriate for intraoperative application according to the neurosurgeon.

Design outcomes

Primary

Measure	Time frame
Sensitivity and specificity of direct cortical and transcranial stimulation, in terms of predicting motor findings upon discharge or 7 days after surgery.	—

Secondary

Measure	Time frame
1-Extent of tumor resection. 2-Clinical motor status 24 hours after surgery, on discharge (or 7 days after surgery) and after 3 months. 3-Barthel Index and Karnofsky performance Score, on discharge and after 3 months. 4-Self reported quality of life (EORTC QOL C30) and depressiveness (BDI-V) 3 months after surgery.	—

Countries

Germany, Switzerland

Contacts

Public ContactTammam Abboud

Universitätsmedizin Göttingen

tammam.abboud@med.uni-goettingen.de0551-39-65246

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026