Patients undergoing orthotopic liver transplantation from deceased donors C22.0 K74.6
Conditions
Interventions
Group 1: 50 patients with liver transplantation will be included. The following parameters will be screened on days 0 to 14 after transplantation: Anamnesis (acute/chronic), general infectology (leuko
Sponsors
Klinik für Anaesthesiologie Universitätsklinikum Heidelberg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: • Liver transplantation at the center of transplantation in Heidelberg • Written and signed informed consent • Age > 18 years
Exclusion criteria
Exclusion criteria: Non-Compliance to the including criteria’s
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Usability of a 29mRNA neuronal network for the prediction of an infection in patients following liver transplantation will be determined. Therefore, routinely collected microbiological findings will be supplemented by pathogen identification toward Next-Generation Sequencing (NGS-) methods. Afterwards, the usability of the neuronal network will be determined. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Patient’s stool sample will be examined for changes within the microbiome to estimate prognostic factor for the prediction of an infection or a rejection. - The values of the clotting factor XIII will be examined in relation to the appearence of unwished events like bleedings, thrombosis and the need of revision surgery | — |
Countries
Germany
Contacts
Public ContactSebastian Decker
Klinik für Anaesthesiologie Universitätsklinikum Heidelberg
Outcome results
None listed