C25 C34
Conditions
Interventions
Group 1: Intervention group (ECC): Supervised combined high intense strength- and aerobic exercise (Intense hypertrophic strength training with eccentric overload [70-80% 1RM + 30% 1RM 'ontop' eccent
8-12reps, 2sets] + moderate aerobic exercise [65-70% maxW, 20min])
2x/week, 24weeks
Group 2: Usual Care (UC), recommandation to regular physical activity, strength- and aerobic exericse, but no supvervised exercise guided by the study.
Sponsors
Uniklinik Köln, Centrum für Integrierte Onkologie, Klinik I für Innere Medizin
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Pancreatic OR lung cancer +cachexia [>5% body weight loss in <6months] + active systemic cancer treatment
Exclusion criteria
Exclusion criteria: ECOG>2 Diseases impaireing exercise capability, such as: - heart insufficiency [NYHA III-IV] - Resperatory insuffiency [partial/global] - permanent trompopenia CTC IV° - coagulation disorders - symptomatic coronary heart disease [stress ECG necessary] - Heavy art. hypertension - COPD in stage IV after GOLD - Uncontrolled epilepsy - Uncontrolled cerebral metastases Medical or mental limitations that, in the investigator's judgment, prohibit participation in the trial or limit the ability to consent Other participation in a exercise study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility (Recruitment, Dropouts, Adverse Events, Compliance) | — |
Secondary
| Measure | Time frame |
|---|---|
| Body composition (BIA), body weight, cachexia progress, cardiopulmonary exercise performance [spiroergometry], strength performance [1RM leg press, 1RM hand grip, 1min sit-to-stand test], ECOG, blood parameter [Albumin, creatinin, CRP, erytrocytes, leukocytes, thrombocytes, Creatinkinase]; patient-related outcomes via questionnaires: quality of life [EORTC-C30]; Fatigue [MFI20], physical acitivity [BSA]; Depression & anxiety [HADS]; cachexia [FAACT]. | — |
Countries
Germany
Contacts
Public ContactTimo Niels
Uniklinik Köln, Centrum für Integrierte Onkologie, Klinik I für Innere Medizin
Outcome results
None listed