Spider phobia Healthy volunteers F20
Conditions
Interventions
Group 1: Patients with schizophrenia and paranoia, single session, total duration of approx. 2 hours:
-Positive And Negative Syndrome Scale, Bern Psychopathology Scale
- Brief Symptom Severity Scale,
Sponsors
Universitäre Psychiatrische Dienste Bern (UPD)Universitätsklinik für Psychiatrie und Psychotherapie
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria of schizophrenia patients with current paranoia: - Informed consent of the patient (given the ability to judge and consent) - Meets the ICD-10 criteria for either schizophrenia (F20), delusional disorder (F22), or psychotic disorder (F23) - Mother tongue German / Swiss German. Inclusion criteria phobic patients: - Informed consent of the patients - Spider phobia (using Fear of Spider Questionnaire) - Mother tongue German / Swiss German. Inclusion criteria control subjects: - Informed consent - Mother tongue German / Swiss German.
Exclusion criteria
Exclusion criteria: Exclusion criteria of schizophrenia patients with current paranoia: - Solicitous placement - Other psychiatric or neurological disorders other than F20, F22 or F23 - Current non-prescribed psychoactive drugs - Drug abuse - Sensory impairments - Inability to consent - Magnetic objects such as implants, pacemakers or pumps in or on the body - Claustrophobia - Pregnancy (urinal pregnancy test will be conducted with every female participant). Exclusion criteria control subjects / Spider phobia: - History of psychiatric or neurological disorders - Current psychoactive drugs - Drug abuse - Sensory impairments - Inability to consent - Staff and students of the project leader and other persons involved in the project - Magnetic objects such as implants, pacemakers or pumps in or on the body - Claustrophobia - Pregnancy (urinal pregnancy test will be conducted with every female participant).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The hemodynamic responses of brain regions derived from the BOLD signal which is recorded using functional MRI at 7T. BOLD signals are contrasted between visual stimulus conditions (faces, spiders, objects) and study groups (schizophrenia, phobia, healhty controls). | — |
Secondary
| Measure | Time frame |
|---|---|
| The group-specific functional and structural connectivity of the brain regions involved in anxiety and fear. Functional connectivity is generally measured by a voxel-wise correlation of the temporal BOLD signal recorded during awake rest. Structural connectivity uses the data obtained from a diffusion tensor imaging sequence. Furthermore, deterministic fibre tracking will be performed to investigate white matter ultrastructure in specific fiber tracts of interest. Lastly, the relationship of the hemodynamic responses with psychological (anxiety questionnaires) measures is analysed. | — |
Countries
Switzerland
Contacts
Public ContactMatthias Grieder
Universitäre Psychiatrische Dienste Bern (UPD)Universitätsklinik für Psychiatrie und Psychotherapie
Outcome results
None listed