E70.0 E70.1
Conditions
Interventions
Group 1: Patients with phenylketonuria (blood withdrawal, physical examination, nutrition questionnaire, life style questionnaire, cognition test)
Group 2: healthy controls (blood withdrawal, physical
Sponsors
Universitätsklinik für Kinder- und Jugendmedizin, St. Josef-Hospital, Ruhr-Universität Bochum
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: = 18 years and written-informed consent
Exclusion criteria
Exclusion criteria: Presence of a metabolic disease other than PKU, missing declaration of consent, patients who are not able to give consent, insufficient knowledge of the German language, Pregnancy and lactation, Pre-terminal or terminal renal failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary hypothesis of the study is that bone health in PKU patients, as measured by significantly different levels of higher BPH (Bone pathology harbinger)-Score, is worse than that of control subjects of the same age and sex and shows further deterioration with increasing Phe levels over the past 5 years. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary hypothesis is that differences between control subjects and PKU patients can also be found in cognitive performance, analyzed with a computer-based cognition test | — |
Countries
Germany
Contacts
Public ContactBeatrice Hanusch
Forschungsdepartment Kinderernährung, Universitätsklinik für Kinder- und Jugendmedizin, St. Josef-Hospital, Ruhr-Universität Bochum
Outcome results
None listed