Neuromuscular and cortical activation after rupture of the anterior cruciate ligament - 1-year follow-up

Neuromuscular and cortical activation after rupture of the anterior cruciate ligament - 1-year follow-up - ACL-FU

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00023002

Enrollment

Registered

2021-03-23

Start date

2022-05-13

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rupture and reconstruction of the anterior cruciate ligament M23.6

Interventions

Group 1: Observation groups: The neuromuscular and cortical activity of participants with anterior cruciate ligament rupture and reconstruction will be observed at 6 measurement time points over the

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: All ACL patients must receive the same surgical repair with a quadriceps tendon graft to be included in the project. In addition, a healthy control group without prior knee pathologies will be included in the project. General inclusion criteria are: - Age between 18 and 50 years - Physically active before the injury (2x 45 minutes per week) (Booth & Lees, 2006) - Clinically confirmed ACL rupture/reconstruction or no previous knee pathology

Exclusion criteria

Exclusion criteria: Previous knee pathology before ACL rupture; injuries of the lower extremity; musculoskeletal diseases; cardiac, neurological or peripheral vascular diseases

Design outcomes

Primary

Measure	Time frame
Primary outcome angle reproduction: neuromuscular activity normalized to gait activity during angular reproduction - Pre-activation - Start of movement to target angle - Activity at target angle - From the target angle to the end point of the movement. Cortical activity in the frontal, central and parietal cortex regions with focus on the following specific frequencies: - theta (4.75-6.75 Hz) - Alpha-1 (7-9.5 Hz) - Alpha-2 (9.75-12.5 Hz). Primary outcome during stair climbing (up/down): Neuromuscular activity normalized for gait activity during angular reproduction divided into the gait phases: - pre-activation - weight acceptance - push off.	—

Measure

Time frame

Primary outcome angle reproduction: neuromuscular activity normalized to gait activity during angular reproduction - Pre-activation - Start of movement to target angle - Activity at target angle - From the target angle to the end point of the movement. Cortical activity in the frontal, central and parietal cortex regions with focus on the following specific frequencies: - theta (4.75-6.75 Hz) - Alpha-1 (7-9.5 Hz) - Alpha-2 (9.75-12.5 Hz). Primary outcome during stair climbing (up/down): Neuromuscular activity normalized for gait activity during angular reproduction divided into the gait phases: - pre-activation - weight acceptance - push off.

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Secondary

Measure	Time frame
Deviation between the target angle and executed angle and movement duration during the angle reproduction test. Jumping distance in meter during the one-leg jumps.	—

Countries

Switzerland

Contacts

Public ContactAglaja Busch

Fachhochschule Bern, Department Gesundheit, Fachbereich Physiotherapie

aglaja.busch@bfh.ch+41 031 848 37 11

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026