N97.0 N97.1 N97.2 N97.3 N97.4 N97.8 N97.9 Z31.2
Conditions
Interventions
Group 1: complete annotation of embryo development until day 3/ day 4 before day 5 of embryonic development
Sponsors
Universitätsklinikum Heidelberg
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: IVF-/ICSI-treatment at Heidelberg University Women's Hospital, fresh cycles, use of time-lapse incubator (EmbryoScope), every patient is only included once
Exclusion criteria
Exclusion criteria: Endometriosis, PCOS, status post chemotherapy, PGT cycles, IVM cycles, embryo transfer before day 5, no transfer due to OHSS (only for secondary outcome implantation rate), developmental arrest before the 8 cell-stage
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Embryo quality according to Gardner and Schoolcraft (1999) at 114-118 hours post-insemination (IVF/ICSI). Categorization according to Cetinkaya et al. (2015): Top Quality (TQ): 3-6AA Good Quality (GQ): 3-6BB, AB oder BA Poor Quality (PQ): Blastocysts of inferior quality. Developmental arrest (AE): Embryos in developmental arrest after the 8-cell stage. Gardner and Schoolcraft, 1999, In vitro culture of human blastocysts, in: Towards reproductive certainty, S. 378-388. Cetinkaya et al., Relative kinetic expressions defining cleavage synchronicity are better predictors of blastocyst formation and quality than absolute time points. J Assist Reprod Genet. 2015;32(1):27-35. doi: 10.1007/s10815-014-0341-x. | — |
Secondary
| Measure | Time frame |
|---|---|
| Implantation rate: The number of gestational sacs observed divided by the number of embryos transferred (expressed as a percentage, %). Zegers-Hochschild et al., 2017, Human Reproduction, 32(9):1786-1801. | — |
Countries
Germany
Contacts
Public ContactVera Garçon
Universitäts-Frauenklinik Heidelberg,Klinik für gynäkologische Endokrinologie und Fertilitätsstörungen
Outcome results
None listed