Prospective clinical study to investigate whether Crohn's disease, ulcerative colitis, multiple sclerosis and systemic scleroderma are associated with an increased prevalence of periodontitis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00022956

Enrollment

Registered

2020-08-28

Start date

2019-02-27

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K50.0 K50.1 A01 K51.0 M34.0 K05.3

Interventions

Group 1: Collection of two samples from any selected sulci (gingival pockets) using a gingival curette (no invasiveness, the collection is comparable to the procedure during a tooth cleaning)

these are placed in cups and then processed in the laboratory unique presentation and collection of parameters, no further presentation necessary

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patient suffers from scleroderma, Crohn's disease, ulcerative colitis or multiple sclerosis Full age patients Initial examination for periodontitis

Exclusion criteria

Exclusion criteria: Patient is already undergoing periodontal treatment Smokers and diabetics, as these are additional risk factors for periodontitis Poor general condition that does not allow for dental diagnostics (retardation, dementia)

Design outcomes

Primary

Measure	Time frame
Is there an increased prevalence of periodontitis in SSc/CED/MS RNA isolation in the laboratory using the trizole method and analysis of different markers (MMP 9 and 2, CD90,CD34 as well as interleukins IL-2,6 and 10) Shock freeze the sample in liquid nitrogen after collection. Storage of the samples at -80°C	—

Secondary

Measure	Time frame
Clinical parameters that correlate with disease and PA Probe Depths PD (6 pages); Cardontal Screening Index PSI O: 3,5mm PD up to 5,5mm 4:>5,5mm Bleeding on probing BOP Suppuration Recession Percussion Clinical Attachemia Loss CAL Degree of loosening Plaque Index according to Mombelli (PI) Grade 0: no plaque detectable by inspection and probing Grade 1: Accumulation of plaque, which is only visible by probing the sulcus with a probe but not with the eye Grade 2: visible plaque deposition Grade 3: massive plaque accumulation unique presentation and collection of parameters, no further presentation necessary	—

Measure

Time frame

Clinical parameters that correlate with disease and PA Probe Depths PD (6 pages); Cardontal Screening Index PSI O: 3,5mm PD up to 5,5mm 4:>5,5mm Bleeding on probing BOP Suppuration Recession Percussion Clinical Attachemia Loss CAL Degree of loosening Plaque Index according to Mombelli (PI) Grade 0: no plaque detectable by inspection and probing Grade 1: Accumulation of plaque, which is only visible by probing the sulcus with a probe but not with the eye Grade 2: visible plaque deposition Grade 3: massive plaque accumulation unique presentation and collection of parameters, no further presentation necessary

—

Countries

Germany

Contacts

Public ContactMayte Buchbender

Mund-Kiefer- und Gesichtschirurgie FAU Erlangen

mayte.buchbender@uk-erlangen.de091318533614

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 21, 2026