A monocentric prospective randomized controlled trial on the effect of crystalloids and colloids on the cardiac stroke volume during neurosurgical spine surgery

A monocentric prospective randomized controlled trial on the effect of crystalloids and colloids on the cardiac stroke volume during neurosurgical spine surgery - Cybolix

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

DRKS

Registry ID

DRKS00022917

Enrollment

Registered

2020-09-04

Start date

2020-10-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M43.9

Interventions

Group 1: fluid bolus of 250ml cristalloid/colloid over a 20 min period Group 2: fluid bolus of 250ml cristalloid/colloid over a 5 min period

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: informed consent male and female patients undergoing neurosurgical spine surgery in prone position (XLIF, TLIF, spondylodesis) Age > 18y ASA I - III general anaesthesia invasive blood pressure monitoring

Exclusion criteria

Exclusion criteria: age stage IIb) chronic kidney disease (> stage II according to KDIGO) pregnancy lack of consent participation in another (interventional) study

Design outcomes

Primary

Measure	Time frame
the change in cardiac stroke volume before and after intervention measured by non-calibrated hemodynamic monitoring	—

Secondary

Measure	Time frame
change in cardiac stroke volume > 10%, requirements for catecholamines (norepinephrine, epinephrine before and after the intervention µg/kg/min), change in mean arterial pressure (MAP), perioperative fluid balance, duration and AUC of hypotension (MAP < 65 mmHg)	—

Countries

Germany

Contacts

Public ContactMichael Sander

Justus-Liebig-Universität GießenKlinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie

martina.galfe@chiru.med.uni-giessen.de004964198544401

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 12, 2026