Healthy volunteers E11 I70
Conditions
Interventions
Group 1: Measurement at one timepoint (Baseline):
- Endo-PAT 2000
- Flow Mediated Dilatation
- Retinal Vessels Analyzer
- Cardio Ankle Vascular Index
- Puls wave velocity
Sponsors
Medizinische Universität Graz
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria Cohort I (Healthy subjects) - Age >18 years - Body mass index in the range of 20.0 – 27.0 kg/m2, - Fasting plasma glucose or capillary glucose 18 years - established diabetes mellitus type 2 on either diet or a monotherapy or combination of metformin, DPP-4-inhibitors, sulfonylurea or SGLT-2 inhibitors Inclusion Criteria Cohort III (Subjects with atherosclerotic lesions) - Age >18 years
Exclusion criteria
Exclusion criteria: Exclusion criteria cohort I (Healthy subjects) - History of cardiovascular disease - Presence of any metabolic disease - Intake of any glucose lowering, lipid lowering or blood pressure lowering medication - acute or chronic inflammatory disorder - heavy drinking (more than 15 drinks/week) - Known Malignancy - Intake of illicit substances - Women who are pregnant, breast-feeding or trying to become pregnant Exclusion criteria cohort II (Subjects with Type 2 Diabetes) - acute or chronic inflammatory disorder - History of cardiovascular disease - heavy drinking (more than 15 drinks/week) - Known Malignancy - Intake of illicit substances -Women who are pregnant, breast-feeding or trying to become pregnant Exclusion criteria cohort III (Subjects with atherosclerosis) - Acute cardiovascular event <3 months - Established type 2 diabetes mellitus - acute or chronic inflammatory disorder - heavy drinking (more than 15 drinks/week) - Known Malignancy - Intake of illicit substances - Women who are pregnant, breast-feeding or trying to become pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of the study is to calculate the correlation between the measurement of endothelial function using Endo-PAT 2000, Flow Mediated Dilatation, Retinal Vessels Analyzer, Cardio Ankle Vascular Index and pulse wave velocity. The measurements are only carried out at one timepoint and are therefore compared at this point in time. | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between the different methods to measure endothelial function in various cohorts investigated. | — |
Countries
Austria
Contacts
Public ContactNorbert Tripolt
Medizinische Universität Graz
Outcome results
None listed