Effects of vagus stimulation by a slow deep breathing technique on the haemodynamics of intermediate coronary stenosis

Effects of vagus stimulation by a slow deep breathing technique on the haemodynamics of intermediate coronary stenosis - REFRESH-4711

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00022888

Enrollment

Registered

2020-09-09

Start date

2020-10-15

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I25.1

Interventions

Group 1: Diagnostic test using invasive physiologic index (Resting full cycle) at rest with determination of the first and second measurement. Performance of slow deep breathing 4711 and determinatio

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Indication for cardiac catheterization with RFR-measurement

Exclusion criteria

Exclusion criteria: Pregnant and lactating women are not included in the study. Persons who are held in custody by court or governmental order will be excluded. Patients who are expected to have problems in conducting the study (dementia, alcohol/drug abuse, known autonomic polyneuropathy, persistent tachycardic atrial arrhythmias, ventricular extrasystole, other serious mental illness) will be excluded.

Design outcomes

Primary

Measure	Time frame
-Proof of an influence of a slow deep breathing technique on the coronary physiology -Feasibility of resonance frequency breathing breathing before, during, and after cardiac catheterization.	—

Secondary

Measure	Time frame
- Correlation of coronary blood flow with the extent of heart rate variability - Safety of cycle breathing during cardiac catheterization - extent of heart rate variability on the amplitude of the invasive blood pressure values - Level of depression and anxiety using Hospital Anxiety and Depression Scale questionnaire - Interoceptive ability using the Multidimensional Assessment of Interoceptive Awareness questionnaire - Self-assessment of the degree of tension immediately before the cardiac catheter examination	—

Measure

Time frame

- Correlation of coronary blood flow with the extent of heart rate variability - Safety of cycle breathing during cardiac catheterization - extent of heart rate variability on the amplitude of the invasive blood pressure values - Level of depression and anxiety using Hospital Anxiety and Depression Scale questionnaire - Interoceptive ability using the Multidimensional Assessment of Interoceptive Awareness questionnaire - Self-assessment of the degree of tension immediately before the cardiac catheter examination

—

Countries

Germany

Contacts

Public ContactHendrik Wienemann

Klinik III für Innere Medizin - Allgemeine und interventionelle Kardiologie, Elektrophysiologie, Angiologie, Pneumologie und internistische Intensivmedizin Universitätsklinikum Köln (AöR)

hendrik.wienemann@uk-koeln.de+49 221 478-32401

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026