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The impact of treatment expectation on the effectiveness and tolerability of prophylaxis in migraine patients

The impact of treatment expectation on the effectiveness and tolerability of prophylaxis in migraine patients

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00022882
Enrollment
134
Registered
2020-12-08
Start date
2017-01-29
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G43.0 G43.1

Interventions

Group 1: Investigate Patients with cronic or episodic migraine by using the CEQ, SF12, GASE, HIT6 and DASS for six months prior to the start of a new migraine prophylaxis or an add on prophylaxis

Sponsors

Klinische NeurowissenschaftenUniversitätsklinikum EssenKlinik für Neurologie
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with episodic or chronic migraine starting a new medical prophylaxis comprising amitriptyline, beta blockers, topiramate, valproic acid, magnesium, flunarizine or onabotulinumtoxinA (new prophylaxis or add on)

Exclusion criteria

Exclusion criteria: pregnancy or breast-feeding missing language skills

Design outcomes

Primary

MeasureTime frame
Development of headache days over the course of 6 months

Secondary

MeasureTime frame
Development of migraine days, pain intensity, pain duration, quality of life, side effects, impairment related to headache, depression, anxiety and stress over a period of 6 months. Differences between responders and non-responders. Differences between patients with and without prior experiences with pharmacological prophylaxis. Influence expectation (CEQ-expectancy) and genetic predispositions (COMT) on all endpoints will be investigated.

Countries

Germany

Contacts

Public ContactTobias Berding

Uniklinikum Essen - Klinik für Neurologie

tobias.berding@uk-essen.de+49 (0) 201 723 - 2446

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026