Prematurity and low birth wieght P07
Conditions
Interventions
Group 1: 45 mothers in the study group (Domperidone group) will take one capsule of Domperidone 10mg three times a day orally for two weeks in the postpartum period.The pre-coded drugs would be given
Sponsors
Kabul University of Medical Science
Eligibility
Sex/Gender
All
Age
4 Days to 35 Years
Inclusion criteria
Inclusion criteria: The mothers aged less than 35y old with preterm delivery and insufficient breast milk (the amount of expressed breast milk become less than the appropriate requirement of babies or the mothers report they have insufficient breast milk) together with their preterm neonates fulfill one of the following criteria will be enrolled in the study. 1-Gestational age of 34 weeks or less. 2-Weight of less than 2000g.
Exclusion criteria
Exclusion criteria: The mothers who have abnormal liver function test, mastitis, twin’s delivery, undergone mastectomy, BMI less than 18, conduction abnormalities on ECG and taking GYP3A4 inhibitors (macrolide, calcium channel blockers, ketoconazole, fluconazole, cimetidine), antipsychotic, antidepressant, tranquilizers, antacids, bromocriptin, and metoclopramide would be excluded from the study. The Neonates have visible or physically detected malformation, birth weight less than 1000g, seriously ill condition, taking probiotic, and the parent who declined consent; are the other exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - The neonatal daily weight gain will be calculated as weight gain in gram during the observation period divided by the number of days in the same period. Neonates must be weighed on day1,7, 14 and 21. - The neonatal weekly enhancement of length and head circumference will be calculated as an increase in length and head circumference in cm during the observation period divided by the number of weeks in the same period. | — |
Secondary
| Measure | Time frame |
|---|---|
| - The risk of neonatal death during the hospital stay. - The risk of maternal breast discomforts including, tenderness, swelling and pain. - The risk of maternal respiratory and gastrointestinal discomforts including difficult breathing, diarrhea, and stomach cramp. - The risk of maternal cardiac arrhythmia detected in ECG. | — |
Countries
Afghanistan
Contacts
Public ContactMansoor Aslamzai
Department of Neonatology, Maiwand Teaching Hospital, Kabul University of Medical Science
Outcome results
None listed