Risk predicition in Covid-19-patients with sepsis/septic shock by means of a combined evaluation of disturbances in microcirculation and hemostasis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00022841

Enrollment

Registered

2021-01-26

Start date

2020-04-24

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

U07.1 R57.2

Interventions

Group 1: measurement of biomarkers (Dipeptidyl peptidase III (DPP III), Proenkephalin, bioactive Adrenomedullin) during inclusion, once every 24h for the first 72h, once after 7d and once after 14d

measurement of Butyrylcholinesterase during inclusion and once every 24h

TIVITA-measurement during inclusion and once every 24h

ROTEM-Analysis during inclusion, once every 24h for the first 72h and once after 7d

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: SARS-CoV-2-infection and SOFA Score = 2

Exclusion criteria

Exclusion criteria: refusal of participation, transfer from intensive care unit within 72h after inclusion probable, pregnancy, palliative therapy, limitation of treatment, probable death of patient, patients that have already been included and are re-admitted to the intensive care unit

Design outcomes

Primary

Measure	Time frame
correlation of hyperspectral imaging Parameters and biomarkers with severity of organ dysfunction using the SOFA Score	—

Secondary

Measure	Time frame
correlation of hyper spectral imaging and biomarkers with 28d mortality after admission to intensive care units, with length of stay on intensive care units, with occurence of cardiovasvular or thrombembolic events, with coagulopathy: disseminated intravascular coagulopathy, bleeding events, Heparin-induced thrombocytopenia (HIT), with necessity of ECLS-therapy in ARDS, with necessity of renal replacement therapy in kidney failure, with development of septic cardiomyopathy, with necessity of liver replacement therapy in liver failure, with pulmonary alterations in CT on admission to intensive care units, with parameters of ventilation (invasivity of ventilation, duration of ventilation), with necessity of hemodynamic support, with hemodynamic parameters (including vital signs, thermodilution monitoring, echocardiography, lung-ultrasound etc.), with occurence of secondary superinfection, with occurence of further organ dysfunction like delirium (septic encephalopathy), critical illness polyneuropathy and myopathy (CIP/CIM)	—

Measure

Time frame

correlation of hyper spectral imaging and biomarkers with 28d mortality after admission to intensive care units, with length of stay on intensive care units, with occurence of cardiovasvular or thrombembolic events, with coagulopathy: disseminated intravascular coagulopathy, bleeding events, Heparin-induced thrombocytopenia (HIT), with necessity of ECLS-therapy in ARDS, with necessity of renal replacement therapy in kidney failure, with development of septic cardiomyopathy, with necessity of liver replacement therapy in liver failure, with pulmonary alterations in CT on admission to intensive care units, with parameters of ventilation (invasivity of ventilation, duration of ventilation), with necessity of hemodynamic support, with hemodynamic parameters (including vital signs, thermodilution monitoring, echocardiography, lung-ultrasound etc.), with occurence of secondary superinfection, with occurence of further organ dysfunction like delirium (septic encephalopathy), critical illness polyneuropathy and myopathy (CIP/CIM)

—

Countries

Germany

Contacts

Public ContactKarsten Schmidt

Universitätsklinikum Essen

karsten.schmidt@uk-essen.de02017231401

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026