A41 R65.1
Conditions
Interventions
Group 1: Only standard diagnostics (Microbial diagnostics by means of standard culture methods + optional consultation of experts in the field of infectious diseases) within the first 72 h after diagn
Sponsors
Universitätsklinikum EssenKlinik für Anästhesiologie und Intensivmedizin
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: All patients who develop sepsis or septic shock within 18 years Sepsis: - Life-threatening organ dysfunction due to a dysregulated immune response on the basis of a suspected or proven infection - Detection of organ dysfunction indicated by SOFA score of = 2 points Alternative: Change of the quick (q) SOFA score of 2 points as an indication of a sepsis Or septic shock: -Persistent hypotension despite adequate volume substitution, which necessitates the use of vasopressors, to maintain an arterial medium pressure of > 65 mmHg -serum lactate > 2 mmol/l (18 mg/dl)
Exclusion criteria
Exclusion criteria: - Age < 18 years - Refusal to participate in the study - Probable discharge of the patient from the intensive care unit within the first 72 h of initial study inclusion - Palliative therapy approach - Death of the patient is already foreseeable or inevitable at trial inclusion - Patients who have already been included in the study but require re-admission to the intensive care unit cannot be included a second time
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DOOR/RADAR (Desirability of Outcome Ranking / Response Adjusted for Duration of Antibiotic Risk)-Score after 28 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| -Mortality rate after 90 and 180 days - Duration of ventilation - Time to resolution of Sepsis - Requirement for follow-up continuous renal replacement therapy - Total hospital stay - Cumulative time of antibiotic requirement - Time at the beginning of the targeted antibiotic -Use of therapeutic services (outpatient and inpatient) - Time out of work - Insurance costs (inpatient and outpatient) - Health-related survey of quality of life | — |
Countries
Germany
Contacts
Public ContactThorsten Brenner
Universitätsklinikum EssenKlinik für Anästhesiologie und Intensivmedizin
Outcome results
None listed