G43.9
Conditions
Interventions
Group 1: Controlgroup, no pharmacological or interventional treatment
Group 2: Migraine Patient group, no pharmacological or interventional treatment
Sponsors
Medizinische Fakultät Mannheim der Universität Heidelberg
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Patients: - Age: 18-40 years - Patients must meet the diagnostic criteria of migraine with or without ICHD-3 aura - Other types of headache may exist in addition to migraine if they can be classified differently by the patient - Migraine episode frequency 1-14/month. - Migraine history for at least one year. First migraine episode at age <50 years - Headache diary kept for 3 months before and 1 month after the examinations - Voluntary, informed consent to participate in the study Healthy Subjects: - Age: 18-40 years - Voluntary, informed consent to participate in the study
Exclusion criteria
Exclusion criteria: Patients: - Patients must not have any contraindications to MRI examinations. - Patients must not have claustrophobia in need of treatment - Patients must not be pregnant. This is ensured by a ß-HCG- test in the urine. - Patients should be free of pain for at least 48 hours before the test. No pain medication should be taken. - Patients should not take centrally effective migraine prophylaxis or coanalgesics (especially anticonvulsants) or centrally attenuating substances (especially opioids). - If a migraine episode occurs in the 24 hours after the measurements, the measurement is stratified as preical. - Patients must be free of neurological and psychiatric diseases that could affect the outcome of the study. Subclinical depressive or anxiety-related symptoms manifested in BDI and STAI are not exclusion criteria. The exclusion criterion is a higher degree of anamnestic impairment of kidney or liver function. Test persons: - No relevant history of episodic headache. Freedom from sporadic headaches for at least 4 weeks before measurement. - Test persons must not have any contraindications to MRI examinations. - Test persons must not have claustrophobia requiring treatment - Test subjects must not be pregnant. This is ensured by a ß-HCG test in the urine. - The test persons must be free of neurological and psychiatric diseases that could affect the outcome of the study. Subclinical depressive or anxiety-related symptoms manifested in BDI and STAI are not exclusion criteria. The exclusion criterion is a higher degree of anamnestic impairment of kidney or liver function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differential changes of electrophysiological and Imaging markers of Attention and distraction under painful stimulation between the groups | — |
Secondary
| Measure | Time frame |
|---|---|
| Overlap of the methods (EEG/ERPs and fMRI) | — |
Countries
Germany
Contacts
Public ContactMatthias Wittayer
Universitätsklinikum Mannheim
Outcome results
None listed