There is currently no evident indication for PGT-A Patients with sub- or infertility N97
Conditions
Interventions
Group 1: retrospective study! Analysis of the number of biopsable embryos and the drop-out rates with regard to PGT without analysis results due to hybridization and amplification errors as well as th
Sponsors
NEXTCLINIC IVF Zentren Prof. Zech, Bregenz
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: All patients who had IVF therapy with PGS / PGT-A analysis performed at the NEXTCLINICS centers in Bregenz, Salzburg (AT), Pilsen (CZ) and Meran (I) between 01/2016 and 04/2020. The specification of which patients have access to a PGS / PGT-A depends on the respective country-specific legal situation. In Austria this is regulated by §2a of the FMedG. Prerequisite for participation is written consent to the pseudonymized evaluation of the medical data in connection with IVF therapy.
Exclusion criteria
Exclusion criteria: PGT-M or PGT-SR candidates, which includes couples whith known translocations or monogenetic diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -Analysis of the proportion of (non-) biopsy viable embryos - analysis of the proportion of embryos in which no PGS / PGT-A result is not obtained after biopsy due to hybridization and amplification errors - percentage of embryos with euploid status / respectively uniform numerical and structural chromosomal aberrations (%) - proportion of mosaic embryos with structural or numerical aberrations (%) - combinations of structural or numerical mosaic (%) - number of remaining blastocysts suitable for transfer according to PGT-A (mean) - clinical outcome parameters after embryo transfer such as pregnancy rate; clinical pregnancy rate; abortion rate; birth rate – -number of IVF cycles required to obtain euploid, transferable blastocysts (mean) | — |
Secondary
| Measure | Time frame |
|---|---|
| It should be examined whether there are possible correlations with regard to the drop-out rate, mosaic rate and (a) anamnestic patient parameters (e.g. type of infertility; male & female age, hormonal stimulation, ..) or (b) possible IVF culture parameters ( eg type of culture medium, morphokinetic parameters, number of biopsied TE cells, location at which the TE cells are removed, ..) | — |
Countries
Austria, Czechia, Italy
Contacts
Public ContactMaximilian Murtinger
NEXTCLINIC IVF Zentren Prof. Zech
Outcome results
None listed