mimimal conscious state G93.80
Conditions
Interventions
Group 1: 1. Standardized clinical assessment:
a. Coma recovery scale (CRS-R): the reaction to diverse stimuli and the spontaneous behavior of the patients will be recorded in the standardized clinical
:
During a MRI examination structural brain lesions and the fiber connections of the brain (DTI) are documented
a functional resting state fMRI is applied to assess the resting activity of the brain
b. Event related potentials (ERP)
The electro-encephalogram is recorded during the patients hear correct or incor
the MRI and the ERP will be assessed as well as the behavioural data (CRS-R, five times) within a 14-day period.
Sponsors
Geschäftsführerin der gemeinnützigen Stiftung Schmieder für Wissenschaft und Forschung;Lurija Institut für Rehabilitationswissenschaften und Gesundheitsforschung
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: - Patients with severe disorders of consciousness and loss of ability to communicate - Type of brain injury/damage: traumatic brain injury, hypoxia, cerebral infarct/bleeding/ subarachnoid hemorrhage, intoxication - Initial examination within a maximum period of 6 month after injury - Legal guardian/representative of the patient give the written informed consent to the study following the principles and guidelines of the Declaration of Helsinki
Exclusion criteria
Exclusion criteria: - contraindication for MRI - bilateral craniectomy - severe extended lesion of the cerebral cortex, e.g. > 2/3 middle cerebral artery territory
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| regaining the reliable ability to communicate | — |
Secondary
| Measure | Time frame |
|---|---|
| - result of the fMRI resting state analysis according to the protocol of Demertzi with differentiation between MCS/UWS - positive N400 in the ERP | — |
Countries
Germany
Contacts
Public ContactThomas Hassa
Lurija Institut für Rehabilitationswissenschaften und Gesundheitsforschung
Outcome results
None listed