Gait control – visuo-motor interactions and plasticity in glaucoma

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00022519

Enrollment

Registered

2020-08-05

Start date

2020-08-20

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

H40

Interventions

Group 1: unimodal movement-related intervention (12 weeks, twice a week, 1h) Group 2: multimodal movement-related intervention (12 weeks, twice a week, 1h)

Eligibility

Sex/Gender

All

Age

60 Years to 100 Years

Inclusion criteria

Inclusion criteria: Patients: open angle glaucoma; Controls: normal visual acuity

Exclusion criteria

Exclusion criteria: other eye diseases except of beginning cataract, ocular trauma, eye surgery (except cataract and glaucoma surgery), neurological and/or orthopedic diseases, e.g. advanced arthrosis, implants of lower extremities, visual acuity < 0.8 for controls

Design outcomes

Primary

Measure	Time frame
Comparison of the effect of uni- and multimodal movement-related intervention (60 min, 2/week, for 12 weeks), comparing pre- (within max. 4 weeks prior to intervention start) and postinterventional data (within max. 3 weeks post intervention end): (a) fMRI-based functional connectivity: Functional connectivity, quantified as seed-to-voxel and ROI-to-ROI correlations of BOLD time-series will be computed between relevant cortical regions as identified in Demirakca et al. (2016) including premotor, primary senso-motor, visual, auditory, dorsolateral prefrontal cortex, frontal eye-fields and midcingulate gyrus. (b) Gait control: gait velocity, gait variability (step lenght, MTC).	—

Measure

Time frame

Comparison of the effect of uni- and multimodal movement-related intervention (60 min, 2/week, for 12 weeks), comparing pre- (within max. 4 weeks prior to intervention start) and postinterventional data (within max. 3 weeks post intervention end): (a) fMRI-based functional connectivity: Functional connectivity, quantified as seed-to-voxel and ROI-to-ROI correlations of BOLD time-series will be computed between relevant cortical regions as identified in Demirakca et al. (2016) including premotor, primary senso-motor, visual, auditory, dorsolateral prefrontal cortex, frontal eye-fields and midcingulate gyrus. (b) Gait control: gait velocity, gait variability (step lenght, MTC).

—

Secondary

Measure	Time frame
Comparison within and across participant groups (controls vs glaucoma) and/or intervention groups (uni- and multimodal intervention) with respect to: (a) fMRI results for functional connectivity, cortical visual field maps, task related responses. (b) Results of eye-movements, cognitive, motor- and visual function, dual-task costs.	—

Countries

Germany

Contacts

Public ContactFrancie;Mustafa Kramer;Sarshar

Otto-von-Guericke Universität Magdeburg Universitäts-Augenklink Leipziger Str. 4439120;Otto-von-Guericke Universität Magdeburg Institut III, Sportwissenschaft

francie.kramer@med.ovgu.de;mustafa.sarshar@ovgu.de0391 67 25233; 0391 67 54936

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026