Changes in bone and surrounding soft tissue structure, metabolism, and vascularisation in Patient with periprosthetic joint infection of the knee and hip

Changes in bone and surrounding soft tissue structure, metabolism, and vascularisation in Patient with periprosthetic joint infection of the knee and hip - JCI-METVASC

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00022515

Enrollment

Registered

2021-11-16

Start date

2020-01-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

T84.5

Interventions

Group 1: Patients with periprosthetic joint infection. Intra-operative specimen collection during prosthesis explantation and reimplantation. The bone and soft tissue samples obtained are analyzed for

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Periprosthetic joint infection of the knee or hip

Exclusion criteria

Exclusion criteria: HIV Hepatitis C, Osteoporosis, No proven periprosthetic joint infection

Design outcomes

Primary

Measure	Time frame
In this study, inflammatory markers in bone and bone marrow are evaluated for elevation in patients with periprosthetic infection compared to the control group.	—

Secondary

Measure	Time frame
In a secondary analysis, markers relevant for bone metabolism are examined in the obtained samples. In addition, a morphological evaluation of the effect on bone metabolism is performed by micro-CT examinations.	—

Countries

Germany

Contacts

Public ContactArne Kienzle

Charité Campus Mitte

arne.kienzle@charite.de030450615139

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026