I95.2 I97.9 T88.5
Conditions
Interventions
Group 1: Induction of general anesthesia with sufentanil, propofol and rocuronium in adult patients prior to elective abdominal or thoracic surgery.
Group 2: Induction of general anesthesia with sufen
Sponsors
Klinik für Anästhesiologie und IntensivtherapieUniversitätsklinikum Carl Gustav Carus
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Medical necessity of invasive blood pressure monitoring (i.e. inserting arterial line) prior to the induction of general anesthesia.
Exclusion criteria
Exclusion criteria: - age 120 kg - ASA score > 4 - emergency operation - hemodynamic instability requiring medical intervention prior to induction (vasopressors, inotropes etc.) - cerebrovascular disease - known carotid stenosis - LVEF 2,25 mg/dl or need for chronic dialysis - liver cirrhosis CHILD B oder C - ACS = 3 months prior - acute hematological malignancy (acute leukemias, lymphomas) - ongoing chemotherapy - history of Raynaud's syndrome - systemic sclerosis - systemic vasculitides - peripheral artery disease additional exclusion criteria for patients receiving esketamine: - hyperthyroidism - ACS = 12 months prior - PCI or CABG = 12 months prior - hydrocephalus - schizophrenia - depression - substance use disorders - bipolar disorder - blood pressure > 190 mmHg systolic upon arrival in the holding bay
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effects of the addition of esketamine to a standardized induction protocol on cutaneous microcirculation (via laser doppler flowmetry, distal-proximal gradient and capillary refilling time). | — |
Secondary
| Measure | Time frame |
|---|---|
| Effekts of the addition of esketamine to a standardized induction protocol on cardiac output (via pulse contour analysis), mean arterial blood pressure and necessary dose of noradrenaline per kilogram of body weight to maintain normal blood pressure. | — |
Countries
Germany
Contacts
Public ContactClaudia Apel
Klinik für Anästhesiologie und Intensivtherapie Universitätsklinikum Dresden
Outcome results
None listed