The effect of forced oral glucose intake on alcohol craving and the mesolimbic stimulus reactivity in the case of alcohol addiction

The effect of forced oral glucose intake on alcohol craving and the mesolimbic stimulus reactivity in the case of alcohol addiction - G-CuP

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00022419

Enrollment

108

Registered

2020-09-15

Start date

2020-08-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcohol dependence F10.2

Interventions

Group 1: Crossover design interventional condition: fMRI to measure the cue reactivity to alcohol cues in patients suffering from an alcohol dependence after a forced oral Glucose intake (80g glucose

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 65 years Diagnosis of alcohol addiction according to ICD 10 Sufficient ability to communicate with the respective study employee, answer questions or process questionnaires Ability to consent after fully written consent (fully informed consent) Written Informed Consent (written consent) Ability to perform functional magnetic resonance imaging

Exclusion criteria

Exclusion criteria: An ICD-10 Axis-I disorder other than alcohol / nicotine addiction or nicotine abuseno Current psychotropic medication Current drug abuse other than nicotine (urine drug screening) Disorder of glucose metabolism (diabetes mellitus I or II) Allergy to bitter almond Aroma Allergy to sodium cyclamate Contraindication against functional magnetic resonance imaging (pregnancy, claustrophobia, implants / metal parts (pacemaker, piercings, braces, spiral) Tattoo / permanent make-up, therapeutic patch (nicotine patch), artificial lenses, epileptic disease) acute threats to oneself / others

Design outcomes

Primary

Measure	Time frame
Differences in subjective craving between the condition including a forced Glucose intake prior to the fMRI and the condition including a forced Placebo intake prior to the scan.	—

Secondary

Measure	Time frame
Differences in the functional brain activity between the condition including a forced Glucose intake prior to the fMRI and the condition including a forced Placebo intake prior to the scan.	—

Countries

Germany

Contacts

Public ContactLea Wetzel

Klinik für abhängiges Verhalten und Suchtmedizin Zentralinstitut für Seelische Gesundheit

Lea.Wetzel@zi-mannheim.de0621/1703-3932

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 11, 2026