Prognostic value of the perioperative platelet function and platelet count in relation to liver regeneration after liver resection

Prognostic value of the perioperative platelet function and platelet count in relation to liver regeneration after liver resection - VoluThromb

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00022414

Enrollment

100

Registered

2020-07-09

Start date

2020-07-06

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C22 C78.7 K73 K74 K75

Interventions

Group 1: Included are patients with indication for partial liver resection. These are further stratified according to the size of the intervention in patients with a resection of less than two liver

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Indication for elective laparoscopic or conventional liver resection (minor and major resections) - ASA I-III

Exclusion criteria

Exclusion criteria: - Preoperative transfusion of thrombocyte concentrates within the last 4 weeks - Basic haematological disease of bone marrow or of thrombocytes (leukemia, lymphoma, MDS, polycytaemia vera, thrombocythemia, thalassemia, etc.) - Known congenital coagulation disorder (protein C/S-deficiency, APC resistance, factor V-Leiden, vWJ syndrome, etc.) - Hypersplenism - Haemodialysis - Cirrhosis of the liver CHILD B or C - Heart failure >NYHA II - Pregnancy - Breastfeeding

Design outcomes

Primary

Measure	Time frame
Co-primary endpoints: - description of the distribution of perioperative changes in platelet function during liver resection - association of perioperative alteration of platelet function with the postoperative platelet count at 1. POD and the perioperative change in platelet count - prognostic value of perioperative changes in platelet function and platelet count in relation to liver regeneration	—

Measure

Time frame

Co-primary endpoints: - description of the distribution of perioperative changes in platelet function during liver resection - association of perioperative alteration of platelet function with the postoperative platelet count at 1. POD and the perioperative change in platelet count - prognostic value of perioperative changes in platelet function and platelet count in relation to liver regeneration

—

Secondary

Measure	Time frame
- Platelet count pre- and postoperative - Platelet function and platelet count on POD 1,3,5,7 - Postoperative liver function - Postoperative liver regeneration (clinical and laboratory chemistry) - Postoperative hypertrophy of residual liver at POD 7 (+/-2 days) and 3 months post-op in all patients with a resection extent of at least 2 anatomical segments using volumetry on the basis of a post-operative MRT - Postoperative hypertrophy of the residual liver at POD 7 (+/-2 days) and 3 months post-op using volumetry based on postoperative ultrasound at POD 5 and 3 months post-op - Prevalence of acute as well as chronic postoperative liver failure stratified by subgroups (group A and B) - Postoperative transfusion of blood products - Postoperative ITS stay and intubation duration - Postoperative morbidity (especially ascites and bile leaks; within the hospital stay and 3 months postoperatively) - Postoperative mortality (within the length of hospital stay and 3 months postoperatively) - Re-operation rate - Intervention rate (bleeding, bile leakage, behaviour) - Histology of the liver parenchyma with scoring for fibrosis/cirrhosis, CASH, steatosis - MR-morphological structural postoperative changes of the liver parenchyma	—

Measure

Time frame

- Platelet count pre- and postoperative - Platelet function and platelet count on POD 1,3,5,7 - Postoperative liver function - Postoperative liver regeneration (clinical and laboratory chemistry) - Postoperative hypertrophy of residual liver at POD 7 (+/-2 days) and 3 months post-op in all patients with a resection extent of at least 2 anatomical segments using volumetry on the basis of a post-operative MRT - Postoperative hypertrophy of the residual liver at POD 7 (+/-2 days) and 3 months post-op using volumetry based on postoperative ultrasound at POD 5 and 3 months post-op - Prevalence of acute as well as chronic postoperative liver failure stratified by subgroups (group A and B) - Postoperative transfusion of blood products - Postoperative ITS stay and intubation duration - Postoperative morbidity (especially ascites and bile leaks; within the hospital stay and 3 months postoperatively) - Postoperative mortality (within the length of hospital stay and 3 months postoperatively) - Re-operation rate - Intervention rate (bleeding, bile leakage, behaviour) - Histology of the liver parenchyma with scoring for fibrosis/cirrhosis, CASH, steatosis - MR-morphological structural postoperative changes of the liver parenchyma

—

Countries

Germany

Contacts

Public ContactCarina Riediger-Schweipert

Universitätsklinikum Carl-Gustav-Carus Dresden an der TU DresdenKlinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie

carina.riediger@ukdd.de+49 (0)351 458 18353

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026