Optimization of exposure therapy by enhancing inhibitory learning mechanisms – Investigation of spider-phobic non-responders to virtual reality exposure therapy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00022379

Enrollment

180

Registered

2020-07-10

Start date

2019-11-25

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F40.2

Interventions

Group 1: Non-Responder to a one-session virtual reality exposure therapy Group 2: Responder to a one-session virtual reality exposure therapy Group 3: Healthy controls

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Responder or Non-responder: Participant in the study of the CRC TRR58 Fear, anxiety and anxiety disorders HC: indidivual without any psychiatric disorder current or lifetime

Exclusion criteria

Exclusion criteria: Exclusion criteria: For healthy control, any current or life-time psychiatric disorder is an exclusion criterion. Further exclusion criteria for all participants are medication, any neurological abnormalities, organic mental disorders, dementia, brain injuries, or MRI contraindications.

Design outcomes

Primary

Measure	Time frame
30% reduction of the score in the Spider Phobia Questionnaire (pre-post)	—

Secondary

Measure	Time frame
a final distance reduction of 50% in the Behavioral avoidance test (pre-post)	—

Countries

Germany

Contacts

Public ContactElisabeth Leehr

Institut für Translationale Psychiatrie

sfbangst@uni-muenster.de+49 251 83-51832

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026