Role of liquid biopsy, analysis of circulating tumor cells and organoids in the diagnostic and therapy of upper-GI and hepato-pancreatico-bilary cancers (GI- and HPB-CA)

Role of liquid biopsy, analysis of circulating tumor cells and organoids in the diagnostic and therapy of upper-GI and hepato-pancreatico-bilary cancers (GI- and HPB-CA) - LiBiCO

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00022375

Enrollment

150

Registered

2022-08-30

Start date

2023-03-01

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C15 C16 C22 C23 C24 C25

Interventions

Group 1: CTC count is determined before/after endoscopy, before/after neoadjuvant therapy, before/after surgical removal, as well as 3 and 6 months thereafter. Cells for organoids are taken at endosco

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with GI- and HPB-CA

Exclusion criteria

Exclusion criteria: Patients with poor condition who cannot tolerate chemotherapy and targeted therapy. Patients with impaired organ functions, heart failure (New York Heart Association III-IV), coronary heart disease, myocardial infarction within 6 months, severe cardiac arrhythmia and respiratory failure. Patients diagnosed with other cancer within 5 years. Patients who are pregnant or breastfeeding. Patients enrolled in other clinical trials or incompliant of regular follow up. Patients who did not provide an informed consent.

Design outcomes

Primary

Measure	Time frame
CTC counts at several timepoints, before/after endoscopy, before/after neoadjuvant therapy and before/after surgery as well as following up after 3 and 6 months.	—

Secondary

Measure	Time frame
Assessment of apoptotic response and infiltration with immune cells in response to standard and immunotherapeutic regimens in tumour organoid cultures of GI-CA and HPB-CA	—

Countries

Germany

Contacts

Public ContactMaximilian Bockhorn

Universitätsklinik für Allgemein- und Viszeralchirurgie, Klinikum Oldenburg

maximilian.bockhorn@uni-oldenburg.de0441 403-2254

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026