L29.9 L28.1
Conditions
Interventions
Group 1: Arm 1: 60 subjects with atopic dermatitis
Arm 2: 60 subjects Prurigo nodularis
Arm 3: 60 subjects with chronic pruritus on non-lesional skin
Arm 4: 60 subjects with healthy skin (healthy cont
Sponsors
Klinik für Hautkrankheiten und Kompentenzzentrum Chronischer Pruritus
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with chronic pruritus (due to atopic dermatitis, chronic scratch lesions or on non lesional skin), Pruritus intensity NRS worst 24h =5; Minimum age 18 years; Skin type I-IV (according to Fitzpatrick); Pruritus present on the forearm; Pruritic lesional skin (dermatosis in AD and PN; pruritic normal looking skin in CP) is present on the forearm; Non-pruritic non-lesional area on the forearm
Exclusion criteria
Exclusion criteria: Patients who are unable to complete the questionnaire due to physical or mental illness or a lack of knowledge of German; Patients with chronic pruritus due to other illnesses; Patients with illness that prevents participation in the examination; Breastfeeding / pregnant women; Patients with neurological disorders such as MS, epilepsy, Parkinson's, Zn stroke, chronic pain syndromes such as fibromyalgia; patients with allergy to substances used, local anesthetics; patients with infections and / or tattoos in the examination area; patients with drug or alcohol addiction; patients who take opioid analgesics permanently; use of Emollients on the day of the examination; external application of moisturizing creams on the day of the examination or 1 week before the start of the examination (top. Capsaicin, top. Steroids, top. Calcineurin inhibitors); patient with tendency to excessive scarring
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of DNA methylation Morphological parameters: epidermal nerve fiber density and neuro-anatomy, caliber deviations, branching, characterization of nerve fibers (myelin, neuropeptides, non-peptidergic markers, receptor expression) Functional parameters: pruritus intensity evoked by cowhage stimulation, Alloknesis, QST Immunostaining: expression of pruritic mediators Gene expression: cutaneous global gene expression profiles, differential expression profiles Determination of DNA methylation Patient questionnaires: NeuroDerm questionnaire, 5PLQ, Itch Controlled Days, ItchyQoL, HADS | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation immunostaining and gene expression | — |
Countries
Germany
Contacts
Public ContactKonstantin Agelopoulos
Klinik für Hautkrankheiten und Kompetenzzentrum chronischer Pruritus, Universitätsklinikum Münster
Outcome results
None listed