Evaluation of physical capacity by handgrip in order to examine the physical capacity, prognosis and response to therapy of patients with pulmonary hypertension

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00022333

Enrollment

154

Registered

2020-07-02

Start date

2020-08-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I27.0 I27.2

Interventions

Group 1: This is an observational study, no intervention arm is planned. Prior to patient recruitment, a handgrip test of healthy persons will be performed in order to observe and quantify a physiolo

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - patients with pulmonary hypertension - signed written informed consent - age 18 and older - healthy subjects without known heart disease

Exclusion criteria

Exclusion criteria: - no handgrip manouever possible - echochardiographic parameters not complying with the inclusion criteria - life expectancy less than twelve months due to a known disease - patients with authorized representatives

Design outcomes

Primary

Measure	Time frame
This is a hypothesis generating study. The primary endpoint is the increase in physical capacity in patients who show a contractile reserve under handgrip, measured by the six minute walking test. The null hypothesis (H0) is: no increase in physical capacity in patients who have a contractile reserve under handgrip. The alternative hypothesis (H1): increase in physical capacity in patients that show a contractile reserve under handgrip.	—

Measure

Time frame

This is a hypothesis generating study. The primary endpoint is the increase in physical capacity in patients who show a contractile reserve under handgrip, measured by the six minute walking test. The null hypothesis (H0) is: no increase in physical capacity in patients who have a contractile reserve under handgrip. The alternative hypothesis (H1): increase in physical capacity in patients that show a contractile reserve under handgrip.

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Secondary

Measure	Time frame
Secondary endpoint is the association of the physical capacity with echo parameters (e.g. PAPsys, TAPSE, S', FAC, RV strain) and the association with mortality and morbidity.	—

Countries

Germany

Contacts

Public ContactChristos Iliadis

Universitätsklinikum Köln

christos.iliadis@uk-koeln.de022147832401

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026