healthy pregnant women O14.9
Conditions
Interventions
Group 1: early-onset preeclampsie (first diagnosis before the 34+0 week of pregnancy and defined along the criteria of national guidelines: elevated blood pressure 140/90mmHg in the pregnancy with new
Sponsors
Universitätsklinikum Leipzig
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Patients with established pre-eclampsia according to national Guidelines and healthy controls with planed cesarean delivery
Exclusion criteria
Exclusion criteria: acute Inflammation/infection of the mother or fetus, fetal abnormalities, autoimmune diseases of the mother or coronary disease, hypertonia or diabetes outside of the pregnancy, pregnancy associated conditions other than pre-eclampsia (e.g. diabetes, placenta praevia), non-singleton pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| activation of thrombocytes in pripheral blood samples, which are taken before the cesarean and analysed directly. Activation of placental inflammasome in placental biopsies done after the cesarean section with immediate Analysis. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Correlation between maternal platelet activation and inflammasome associated cytokines in plasma 2) Association between placental NLRP3 expression and maternal platelet activation 3) Cell specific molecular analysis using scRNA seq | — |
Countries
Germany
Contacts
Public ContactHolger Stepan
Universitätsklinikum Leipzig
Outcome results
None listed