Influence of NMB reversal on early neurocognitive function after general anesthesia.

Influence of NMB reversal on early neurocognitive function after general anesthesia. - CASA

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00022242

Enrollment

Registered

2020-09-04

Start date

2020-12-29

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurocognitive function G97.9 U51.02

Interventions

Group 1: Group reversal NMB: MoCA, vital parameters, subjective condition evaluated by patient + observer, in each case pre-op and in the postoperative course 4 x up to 7 days post-op + follow-up. Col

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: ASA I-III, planned ITN, elective small to medium-sized surgery

Exclusion criteria

Exclusion criteria: Neurological disease with MoCA <26/30; polyneuropathy; chronic pain; use of retarded opioids; history of substance abuse; perioperative use of: clonidine, diphenhydramine, droperidol, ketamine, midazolam; perioperative transfusion; known pregnancy or lactation.

Design outcomes

Primary

Measure	Time frame
neurocognitive assessment using the MoCA score (vs. 7.1-7.3 and 8.1-8.3) preOP, 0-15 min (Mini-MoCA), 3 times during the PACU stay, once before discharge, after 30 days	—

Secondary

Measure	Time frame
Subjective assessment of alertness, EEG change (alpha power), plasma level of fentanyl during the course, O2 saturation,	—

Countries

Germany

Contacts

Public ContactSebastian Zinn

Universitätsklinikum Frankfurt Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie

zinn@med.uni-frankfurt.de+4969630187420

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026