Intraoperative one-lung ventilation
Conditions
Interventions
Group 1: Conventional volume-controlled one-lung ventilation
Group 2: Variable volume-controlled one-lung ventilation
Sponsors
Technische Universität Dresden
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patients with planned thoracic surgery (open or video-assisted) under one-lung ventilation using a double lumen tube and invasive monitoring of arterial blood pressure - ASA = 3 - Planned duration of intervention > 30 min - Age = 18 - Weight > 40 kg - Written consent of the participating person
Exclusion criteria
Exclusion criteria: - COPD GOLD grade 3 and 4 - Untreated asthma - Lung separation using a method other than DLT (e.g. difficult airway, tracheostomy) - Contraindications against total intravenous anaesthesia - History of hypersensitivity/allergy to one of the medications to be used or their ingredients or to medication with a similar chemical structure - Participation of the patient in another clinical trial within the last 4 weeks before inclusion - Addictions or other illnesses which do not allow the person concerned to assess the nature and extent of the clinical trial and its possible consequences - Pregnant or breastfeeding women - Women of childbearing age, except women who meet the following criteria: > Post-menopausal (12 months natural amenorrhoea or 6 months amenorrhoea with serum FSH > 40 mlU/ml) > Postoperative (6 weeks after bilateral ovarectomy with or without hysterectomy) > Regular and correct use of a Contraceptive method with a failure rate < 1% per year (e.g. implants, depot injections, oral contraceptives, intrauterine device - IUD).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary end point is the arterial oxygen partial pressure (PaO2) 20 min after initiation of one-lung ventilation. | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) Intraoperative complications (2) Necessity of intraoperative rescue maneuvers in case of gas exchange disturbances (3) Need for intraoperative rescue maneuvers in cases of hemodynamic instability (4) postoperative pulmonary and extrapulmonary complications (5) advanced postoperative pulmonary complications (6) arterial blood gas analyses during dual and single lung ventilation (pCO2, pO2, pH) (7) PaO2/FIO2 after OP end (8) Intraoperative respiratory mechanics (9) Mechanical Power (10) Length of hospital stay (11) Number of days spent at home on the postoperative day 30 after surgery | — |
Countries
Germany
Contacts
Public ContactMarcelo Gama de Abreu
Universitätsklinikum Carl Gustav Carus
Outcome results
None listed