Observational study to characterize the pathogenesis of acute-on-chronic liver failure

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00022124

Enrollment

1200

Registered

2021-07-08

Start date

2021-03-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K74.2 K72.1

Interventions

Group 1: SAPIENT = Sepsis ACLF PatIENTs Evaluation of clinical and laboratory parameters and organ failures in the context of sepsis in ACLF Group 2: PROACT = PoRtal mediatOrs as ACLF Targets Eval

Eligibility

Sex/Gender

All

Age

18 Years to 88 Years

Inclusion criteria

Inclusion criteria: SAPIENT: ACLF with Need for intensive care PROACT: ACLF with indication for TIPS ELITE: ALCF with indication for liver transplantation

Exclusion criteria

Exclusion criteria: - HCC outside MILAN criteria or other malignoma - hereditary or acquired immune deficiency - pregnancy

Design outcomes

Primary

Measure	Time frame
Mortality - surveillance of the clinical courses of ACLF patients in each of the three study arms and survival analysis (28-day, 90-day, and 1-year mortality)	—

Countries

Germany

Contacts

Public ContactJonel Trebicka

Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main

Jennifer.Biondo@kgu.de+49 (0)69 6301 80789

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026