Differences in physiological responses to cardio-pulmonary exercise testing in adults with type 1 diabetes and healthy individuals – a pooled analysis

Differences in physiological responses to cardio-pulmonary exercise testing in adults with type 1 diabetes and healthy individuals – a pooled analysis - CPX and T1D

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00022106

Enrollment

700

Registered

2020-07-10

Start date

2020-06-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E10

Interventions

Group 1: Data: Adults with type 1 diabetes that conducted a cardio-pulmonary exercise test on a cycle ergometer. Group 2: Data: Adults without type 1 diabetes that conducted a cardio-pulmonary exercis

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Data: - Individuals with a clinical diagnosis of type 1 diabetes - Individuals without any metabolic disease - CPX test including the following parameters: protocol, vt1, vt2, max, heart rate, VE, VO2, VCO2, BMI, age, diabetes duration (if applicable), hba1c (if applicable).

Exclusion criteria

Exclusion criteria: Data: - No cardio-pulmonary exercise test conducted - If specific parameters were missing such as: protocol, vt1, vt2, max, heart rate, VE, VO2, VCO2, BMI, age, diabetes duration (if applicable), Hba1c (if applicable)

Design outcomes

Primary

Measure	Time frame
To investigate the relative oxygen consumption over the course of a cardio-pulmonary exercise test (VT1, VT2, peak) in individuals with type 1 diabetes compared against non-diabetic individuals.	—

Secondary

Measure	Time frame
• To investigate the heart rate (bpm) over the course of a cardio-pulmonary exercise test (VT1, VT2, peak) in individuals with type 1 diabetes compared against healthy individuals • To investigate the power (W) over the course of a cardio-pulmonary exercise test (VT1, VT2, peak) in individuals with type 1 diabetes compared against healthy individuals • To compare heart rate to performance curves (kHR) during cardio-pulmonary exercise tests in individuals with type 1 diabetes against healthy individuals • To find associations of specific anthropometric (age, BMI, gender) and diabetes specific characteristics (c-peptide level, HbA1c, diabetes duration, total daily insulin dose) influencing maximum and submaximal physiological responses during cardio-pulmonary exercise testing in individuals with type 1 diabetes • To find association of specific anthropometric (age, BMI, gender) influencing maximum and submaximal physiological responses during cardio-pulmonary exercise testing in healthy individuals	—

Measure

Time frame

• To investigate the heart rate (bpm) over the course of a cardio-pulmonary exercise test (VT1, VT2, peak) in individuals with type 1 diabetes compared against healthy individuals • To investigate the power (W) over the course of a cardio-pulmonary exercise test (VT1, VT2, peak) in individuals with type 1 diabetes compared against healthy individuals • To compare heart rate to performance curves (kHR) during cardio-pulmonary exercise tests in individuals with type 1 diabetes against healthy individuals • To find associations of specific anthropometric (age, BMI, gender) and diabetes specific characteristics (c-peptide level, HbA1c, diabetes duration, total daily insulin dose) influencing maximum and submaximal physiological responses during cardio-pulmonary exercise testing in individuals with type 1 diabetes • To find association of specific anthropometric (age, BMI, gender) influencing maximum and submaximal physiological responses during cardio-pulmonary exercise testing in healthy individuals

—

Countries

Austria, Brazil, Germany, Switzerland, United Kingdom

Contacts

Public ContactOthmar Moser

Klinische Abteilung für Endokrinologie und Diabetologie

othmar.moser@medunigraz.at+43316 385 83544

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026